Orthogen
Generic Name
Osteoregeneron 20 mg tablet
Manufacturer
PharmaJoint Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orthogen 20 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Orthogen 20 mg Tablet is a medication used for the treatment of osteoarthritis, aiming to reduce pain, improve joint function, and potentially slow down cartilage degradation. It is believed to support cartilage regeneration processes.
Uses & Indications
Dosage
Adults
One 20 mg tablet once daily.
Elderly
No specific dose adjustment required, but caution advised.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment (e.g., reduce to 10 mg daily or alternate day dosing).
How to Take
Take orally with water, preferably after a meal to minimize gastrointestinal discomfort.
Mechanism of Action
Orthogen (Osteoregeneron) is believed to exert its effects by modulating inflammatory pathways and stimulating chondrocyte activity, promoting the synthesis of extracellular matrix components necessary for cartilage repair and maintenance. It may also inhibit enzymes responsible for cartilage breakdown.
Pharmacokinetics
Onset
Initial effects on pain and mobility within 2-4 weeks, significant effects after 3-6 months.
Excretion
Excreted mainly through urine, with a small portion via feces.
Half life
Approximately 8-12 hours.
Absorption
Well absorbed orally, with peak plasma concentrations reached within 2-4 hours.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Osteoregeneron or any component of the tablet
- Severe hepatic impairment
- Severe renal failure (CrCl < 30 mL/min)
Drug Interactions
NSAIDs
Concurrent use with NSAIDs may increase the risk of gastrointestinal side effects.
Warfarin
May enhance the anticoagulant effect of warfarin, increasing risk of bleeding. Monitor INR closely.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe gastrointestinal upset. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use in pregnancy and lactation is not recommended due to insufficient data. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patented
Clinical Trials
Ongoing Phase III trials are evaluating its long-term efficacy and safety in diverse patient populations.
Lab Monitoring
- Liver function tests (periodically, especially with long-term use)
- Renal function tests (for patients with pre-existing impairment)
Doctor Notes
- Advise patients on lifestyle modifications.
- Educate on the chronic nature of osteoarthritis and the need for adherence.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy weight.
- Engage in regular low-impact exercise.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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