Medicine Information

Pantex

Name: Pantex
Brand: Pantex
Rating: 4.5 (117 reviews)

Tablet40 mgProton Pump Inhibitor (PPI)ATC: A02BC02

Generic Name

Pantoprazole 40 mg

Manufacturer

Popular Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
pantex 40 mg tablet	৳ 8.00	৳ 80.00

Description

Overview of the medicine

Pantex 40 mg tablet contains Pantoprazole, which is a proton pump inhibitor used to treat conditions involving excess stomach acid. It works by irreversibly blocking the proton pumps in the stomach lining, thereby reducing acid production.

Uses & Indications

Gastroesophageal Reflux Disease (GERD)

Erosive Esophagitis

Zollinger-Ellison Syndrome and other pathological hypersecretory conditions

Duodenal Ulcer

Gastric Ulcer

Eradication of Helicobacter pylori (in combination with antibiotics)

Dosage

Adults

GERD/Erosive Esophagitis: 40 mg once daily for up to 8 weeks. Maintenance: 20-40 mg daily. Duodenal/Gastric Ulcer: 40 mg once daily for 2-4 weeks. H. pylori eradication: 40 mg twice daily for 7-14 days (with antibiotics). Zollinger-Ellison Syndrome: Initial dose 40 mg twice daily, adjusted as needed.

Elderly

No dosage adjustment generally required, but close monitoring is advisable.

Renal_impairment

No dosage adjustment required.

Hepatic_impairment

For severe hepatic impairment, a maximum dose of 20 mg once daily may be considered.

How to Take

Take the tablet whole with a glass of water, usually 30-60 minutes before a meal. Do not crush, chew, or break the tablet.

Mechanism of Action

Pantoprazole is a substituted benzimidazole that inhibits gastric acid secretion by irreversibly binding to the H+/K+-ATPase enzyme (proton pump) in the secretory canaliculi of the gastric parietal cells. This action blocks the final step in acid production, regardless of the stimulus, leading to a profound and long-lasting inhibition of gastric acid secretion.

Pharmacokinetics

Onset

Onset of action within 2.5 hours.

Excretion

Mainly excreted in urine (approximately 80%) and feces (approximately 18%) as metabolites.

Half life

Approximately 1 hour (terminal elimination half-life is longer, up to 7-9 hours after repeated dosing due to sustained acid suppression).

Absorption

Rapidly absorbed after oral administration. Bioavailability is approximately 77% and is not affected by food.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 (CYP) system, primarily CYP2C19 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to pantoprazole or any component of the formulation
Known hypersensitivity to substituted benzimidazoles

Drug Interactions

Warfarin

Increased INR and prothrombin time, monitor carefully.

Methotrexate

Increased and prolonged elevation of methotrexate levels, especially with high doses.

Atazanavir, Nelfinavir

Reduced absorption, avoid co-administration.

Ketoconazole, Itraconazole, Erlotinib

Absorption depends on gastric pH, may reduce bioavailability.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

In case of overdose, supportive and symptomatic treatment should be initiated. Pantoprazole is not significantly removed by hemodialysis. There is no specific antidote.

Pregnancy & Lactation

Pregnancy Category B. Use only if clearly needed. Excreted in human milk, use with caution during lactation and weigh the benefits against potential risks.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10)30 tablets (3x10)50 tablets (5x10)

Shelf Life

Typically 24 to 36 months from the date of manufacture.

Availability

Available in pharmacies nationwide

Approval Status

Approved by DGDA/FDA equivalent bodies worldwide

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated pantoprazole's efficacy and safety in various acid-related disorders. Ongoing research continues to explore its long-term effects and new indications.

Lab Monitoring

Monitor magnesium levels, especially in patients on long-term therapy or concomitant diuretics. Assess vitamin B12 levels in patients on long-term therapy (>3 years).

Doctor Notes

Consider lowest effective dose and shortest duration for PPI therapy.
Assess need for continued PPI therapy periodically.
Be aware of potential drug interactions, especially with warfarin, methotrexate, and antiretrovirals.
Educate patients on potential long-term risks with chronic use.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not crush, chew, or break the tablet; swallow it whole.
For best results, take it 30-60 minutes before your first meal of the day.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Pantoprazole generally does not impair the ability to drive or operate machinery. However, if side effects like dizziness or visual disturbances occur, caution should be exercised.