Medicine Information

Probac

Name: Probac
Brand: Probac
Rating: 4.5 (117 reviews)

Oral Suspension2 billion spores/5 ml (125 mg)ProbioticATC: A07FA01

Generic Name

Bacillus clausii oral suspension

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
probac 125 mg suspension	৳ 198.66	N/A

Description

Overview of the medicine

Probac 125 mg Suspension is an oral probiotic preparation containing Bacillus clausii spores, used to restore the balance of intestinal flora and improve digestive health. It is particularly useful during and after antibiotic treatment.

Uses & Indications

Treatment and prevention of intestinal dysbiosis

Treatment of acute and chronic gastrointestinal disorders in infants and adults (e.g., diarrhea, constipation)

Restoration of intestinal flora during and after antibiotic treatment

Supportive treatment for malabsorption syndromes

Dosage

Adults

1-2 vials (5-10 ml) per day, orally. May be diluted in water, milk, tea or orange juice.

Elderly

Same as adult dosage.

Renal_impairment

No dosage adjustment required.

How to Take

Shake the vial before use. The content of the vial should be taken as it is or diluted in water, milk, tea or orange juice. Administer at regular intervals throughout the day. Do not exceed recommended dose.

Mechanism of Action

Bacillus clausii spores survive gastric acidity and germinate in the intestinal tract, restoring the balance of the intestinal flora. They produce various vitamins, especially B group vitamins, and exhibit antibiotic resistance, making them effective during antibiotic therapy. They also modulate the immune system.

Pharmacokinetics

Onset

Effects may be observed within a few days of consistent use.

Excretion

Excreted via feces.

Half life

Not applicable as it's a living microorganism acting locally.

Absorption

Bacillus clausii spores are not absorbed systemically; they act locally in the gastrointestinal tract.

Metabolism

Not applicable; spores germinate and multiply in the gut, then are excreted.

Side Effects

Contraindications

Hypersensitivity to the active substance or to any of the excipients.

Drug Interactions

Antibiotics

Bacillus clausii is resistant to many common antibiotics, allowing it to be administered between antibiotic doses to maintain gut flora. However, it is advisable to take probiotics a few hours apart from antibiotic doses.

Storage

Store below 30°C. Do not freeze. Protect from light.

Overdose

No specific overdose symptoms are known for Bacillus clausii spores. Probiotics generally have a high safety profile. In case of suspected overdose, contact a healthcare professional.

Pregnancy & Lactation

Considered safe during pregnancy and lactation, but consultation with a healthcare professional is always recommended.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 vials per pack20 vials per pack

Shelf Life

Usually 24-36 months from manufacturing date.

Availability

Pharmacies, drug stores

Approval Status

Approved by regulatory authorities (e.g., DGDA)

Patent Status

Expired or not applicable (for generic strains)

Clinical Trials

Numerous clinical trials have demonstrated the efficacy of Bacillus clausii in treating various gastrointestinal disorders and preventing antibiotic-associated diarrhea.

Lab Monitoring

No specific laboratory monitoring is required for this probiotic.

Doctor Notes

Advise patients to complete the full course of treatment as prescribed, especially when used with antibiotics.
Counsel on proper administration technique (shaking vial, mixing with appropriate liquids).

Patient Guidelines

Read the leaflet carefully before use.
Do not exceed the recommended dose.
Store in a cool, dry place, away from direct sunlight.
Keep out of reach of children.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.