Medicine Information

A-Clox

Name: A-Clox
Brand: A-Clox
Rating: 4.5 (117 reviews)

Powder for InjectionAmpicillin 250 mg + Cloxacillin 250 mg (Total 500 mg)AntibioticsATC: J01CR

Generic Name

Ampicillin Trihydrate + Cloxacillin Sodium

Manufacturer

ACME Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
a clox 500 mg injection	৳ 28.40	N/A

Description

Overview of the medicine

A-Clox 500 mg Injection is a combination antibiotic used to treat a wide range of bacterial infections, especially those caused by beta-lactamase producing strains. It contains Ampicillin, a broad-spectrum penicillin, and Cloxacillin, a penicillinase-resistant penicillin.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia)

Skin and soft tissue infections (e.g., cellulitis, carbuncles)

Urinary tract infections (e.g., cystitis, pyelonephritis)

Septicemia and endocarditis

Surgical prophylaxis and treatment of post-operative infections

Bone and joint infections

Gastrointestinal infections

Dosage

Adults

500 mg to 1 g (Ampicillin + Cloxacillin) every 6 hours by IM or slow IV injection. The dose may be increased in severe infections.

Elderly

Similar to adult dosage, but caution should be exercised and dosage adjustment may be necessary in patients with impaired renal function.

Renal_impairment

Dose reduction is required based on creatinine clearance. For CrCl < 10 mL/min, extend dosing interval to 8-12 hours.

How to Take

For IM administration, reconstitute the powder with sterile water for injection. For IV administration, reconstitute and then dilute with a suitable intravenous fluid (e.g., normal saline, dextrose). Administer slowly over 3-5 minutes for IV push or infuse over 30-60 minutes.

Mechanism of Action

Both Ampicillin and Cloxacillin act by inhibiting bacterial cell wall synthesis, leading to cell lysis and bacterial death. Ampicillin provides broad-spectrum activity against many Gram-positive and Gram-negative bacteria, while Cloxacillin adds resistance to degradation by bacterial beta-lactamase enzymes.

Pharmacokinetics

Onset

Rapid onset, typically within minutes for IV administration and 15-30 minutes for IM.

Excretion

Primarily excreted unchanged in the urine via glomerular filtration and tubular secretion. A small amount is excreted in bile.

Half life

Approximately 0.5-1.5 hours for both components in individuals with normal renal function.

Absorption

Rapidly absorbed after intramuscular (IM) injection. Intravenous (IV) administration achieves immediate systemic concentrations.

Metabolism

Minimal hepatic metabolism, primarily excreted unchanged.

Side Effects

Contraindications

Known hypersensitivity to penicillins, cephalosporins, or any component of the formulation.
Patients with a history of penicillin-associated cholestatic jaundice/hepatic dysfunction.

Drug Interactions

Probenecid

Increases and prolongs plasma levels of ampicillin and cloxacillin by competing for renal tubular secretion.

Tetracyclines

May antagonize the bactericidal effect of penicillin antibiotics.

Anticoagulants

May potentiate the effect of anticoagulants (e.g., warfarin) by altering gut flora and reducing vitamin K synthesis.

Oral Contraceptives

May reduce the efficacy of oral contraceptives; additional contraceptive methods should be considered.

Storage

Store the dry powder below 30°C, protected from light and moisture. Do not freeze. Refer to the manufacturer's instructions for the storage of the reconstituted solution.

Overdose

Overdose may lead to neurological toxicities including seizures, especially in patients with impaired renal function. Management is primarily symptomatic and supportive. Hemodialysis may be useful in enhancing elimination.

Pregnancy & Lactation

Pregnancy Category B. Generally considered safe for use during pregnancy, but should be used only if clearly needed. Both ampicillin and cloxacillin are excreted in breast milk; caution is advised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

Single vial with diluentBox of 10 vials

Shelf Life

Typically 2-3 years when stored as per recommendations. Reconstituted solution has a shorter shelf life (e.g., 24 hours at room temperature or 7 days under refrigeration).

Availability

Hospitals, Clinics, Pharmacies

Approval Status

DGDA Approved

Patent Status

Generic

WHO Essential Medicine

Yes

Clinical Trials

The efficacy and safety of Ampicillin and Cloxacillin combination have been established through numerous clinical trials and extensive clinical use over decades for various bacterial infections.

Lab Monitoring

Monitor renal function (creatinine, BUN) periodically, especially in patients with pre-existing renal impairment or during prolonged therapy.
Complete blood count (CBC) for prolonged therapy.
Liver function tests (ALT, AST) if hepatic dysfunction is suspected or during long-term treatment.

Doctor Notes

Always perform culture and sensitivity testing prior to initiating treatment, if feasible.
Monitor renal function, especially in elderly or renally impaired patients, and adjust dosage accordingly.
Advise patients about the importance of completing the full course of therapy to prevent resistance.
Be vigilant for signs of hypersensitivity reactions, including anaphylaxis.

Patient Guidelines

Complete the full course of treatment as prescribed by your doctor, even if symptoms improve earlier.
Report any severe or persistent side effects to your doctor immediately.
Inform your doctor about all other medications, supplements, and herbal products you are taking.
Do not share this medicine with others, even if they have similar symptoms.

Missed Dose Advice

If a dose is missed, administer it as soon as remembered, unless it is almost time for the next dose. In that case, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

A-Clox 500 mg Injection is not known to impair the ability to drive or operate machinery. However, if you experience dizziness or severe allergic reactions, avoid such activities.