Medicine Information

Acunac

Name: Acunac
Brand: Acunac
Rating: 4.5 (117 reviews)

Eye Drop0.5% w/vOphthalmic NSAIDsATC: S01BC05

Generic Name

Ketorolac Tromethamine Ophthalmic Solution

Manufacturer

Acme Pharmaceuticals

Country

Global

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
acunac 009 eye drop	৳ 100.30	N/A

Description

Overview of the medicine

Acunac-009 eye drop is an ophthalmic solution containing Ketorolac Tromethamine, a nonsteroidal anti-inflammatory drug (NSAID). It is used to reduce inflammation and pain in the eyes, particularly after cataract surgery.

Uses & Indications

For the treatment of ocular itching associated with seasonal allergic conjunctivitis.

For the treatment of postoperative inflammation following cataract extraction.

Dosage

Adults

For seasonal allergic conjunctivitis: 1 drop into the affected eye(s) four times a day. For postoperative inflammation: 1 drop into the affected eye(s) four times a day, beginning 24 hours after surgery and continuing for up to two weeks.

Elderly

No dosage adjustment is generally required for elderly patients.

Renal_impairment

No dosage adjustment is generally required for ophthalmic use in patients with renal impairment.

How to Take

For ophthalmic use only. Tilt head back, pull down the lower eyelid to create a pouch, and instill one drop. Do not touch the dropper tip to any surface to avoid contamination. If using other eye drops, wait at least 5 minutes between applications.

Mechanism of Action

Ketorolac tromethamine inhibits prostaglandin synthesis by irreversibly inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. Prostaglandins are mediators of inflammation and pain. By reducing prostaglandin levels, Acunac-009 helps to alleviate ocular inflammation and associated pain.

Pharmacokinetics

Onset

Onset of analgesic and anti-inflammatory action can be expected within an hour of administration.

Excretion

Mainly excreted in the urine, with a small portion excreted in feces.

Half life

The systemic half-life is approximately 5-6 hours, but local therapeutic effect in the eye is more relevant.

Absorption

Minimal systemic absorption occurs after ophthalmic administration. Peak plasma concentrations are very low (ng/mL range) and generally undetectable.

Metabolism

Systemically absorbed ketorolac is extensively metabolized in the liver, primarily via glucuronidation.

Side Effects

Contraindications

Hypersensitivity to Ketorolac Tromethamine or any component of the formulation.
Patients with a history of hypersensitivity to other NSAIDs (e.g., aspirin, ibuprofen) where symptoms of asthma, acute rhinitis, urticaria, angioedema, or bronchospasm have occurred.
Concurrent use with other topical ocular NSAIDs.

Drug Interactions

Topical Ocular Corticosteroids

May impair healing or exacerbate corneal complications, especially in predisposed patients. Use with caution.

Storage

Store at room temperature below 30°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

Ophthalmic overdose is unlikely to cause systemic toxicity due to minimal systemic absorption. If accidentally ingested, symptomatic and supportive treatment should be initiated.

Pregnancy & Lactation

Pregnancy Category C (first two trimesters) and D (third trimester). Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing woman, as systemic absorption is minimal but possible.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 mL bottle10 mL bottle

Shelf Life

Typically 24 to 36 months when unopened. Once opened, discard after 28 days to prevent contamination.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic available

Clinical Trials

Clinical trials have demonstrated the efficacy of ophthalmic ketorolac in reducing postoperative ocular inflammation and pain, as well as in treating ocular itching associated with seasonal allergic conjunctivitis. Studies have shown comparable efficacy to other ophthalmic NSAIDs.

Lab Monitoring

No specific lab monitoring is typically required for ophthalmic use.

Doctor Notes

Counsel patients on proper administration technique to avoid contamination and maximize efficacy.
Monitor patients for signs of corneal complications, especially with prolonged use or in high-risk individuals.
Advise against concurrent use of other ocular NSAIDs and exercise caution with topical corticosteroids.

Patient Guidelines

Wash hands thoroughly before use.
Remove contact lenses before applying the eye drop and wait at least 15 minutes before reinserting them.
Avoid touching the tip of the dropper to your eye or any other surface to prevent contamination.
Close your eye gently after instilling the drop and press lightly on the inner corner of your eye for a minute to prevent the drop from draining out.
Do not wear contact lenses if your eyes are inflamed or infected.

Missed Dose Advice

If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not use two doses at once.

Driving Precautions

Acunac-009 eye drop may cause temporary blurring of vision after administration. Patients should be advised to wait until their vision clears before driving or operating machinery.

Lifestyle Advice

Avoid rubbing your eyes, especially after eye surgery or if experiencing inflammation.
If you experience sensitivity to light, wear sunglasses when outdoors.