arodin
Generic Name
Povidone-Iodine
Manufacturer
Example Pharma Ltd.
Country
Bangladesh (example)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| arodin 5 w ointment | ৳ 22.00 | N/A |
Description
Overview of the medicine
Arodin-5-W Ointment contains Povidone-Iodine 5% w/w, an antiseptic agent used to prevent and treat skin infections in minor cuts, scrapes, and burns. It works by releasing iodine, which kills a wide range of bacteria, fungi, viruses, and protozoa.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected area once or twice daily, or as directed by a healthcare professional.
Elderly
No specific dosage adjustment required for elderly patients; apply as for adults.
Renal_impairment
Use with caution in patients with severe renal impairment due to potential for systemic iodine absorption. Consult a healthcare professional.
How to Take
Clean the affected area. Apply a thin layer of ointment directly to the skin or spread on a sterile gauze pad and apply to the affected area. Cover with a sterile dressing if necessary.
Mechanism of Action
Povidone-Iodine works by releasing free iodine upon contact with skin and mucous membranes. The free iodine rapidly penetrates microbial cell walls and oxidizes proteins, nucleotides, and fatty acids, leading to cell death. It has broad-spectrum antimicrobial activity against gram-positive and gram-negative bacteria, fungi, viruses, mycobacteria, and protozoa.
Pharmacokinetics
Onset
Within seconds to minutes for antimicrobial action.
Excretion
Mainly excreted renally as iodide. Some excretion via feces.
Half life
Systemic half-life of absorbed iodine is approximately 1-2 days, but topical action is localized.
Absorption
Minimally absorbed systemically through intact skin. Significant absorption can occur through large areas of denuded skin or mucous membranes.
Metabolism
Systemically absorbed iodine is metabolized in the thyroid gland.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone.
- Patients with thyroid disorders (e.g., hyperthyroidism, goiter) due to potential for iodine absorption.
- Infants under 1 month (due to skin permeability and risk of systemic absorption).
- Before and after radioiodine therapy.
Drug Interactions
Lithium
Concurrent use may lead to hypothyroidism, especially in patients with pre-existing thyroid conditions.
Octenidine
Should not be used simultaneously or sequentially with octenidine-containing antiseptics on adjacent or extensive areas, as this may cause transient skin discoloration or necrosis.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause serious systemic effects unless applied to very large areas of broken skin. Symptoms of systemic iodine toxicity include gastrointestinal upset, metabolic acidosis, renal impairment, and thyroid dysfunction. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use with caution. Excessive absorption of iodine can affect fetal thyroid development or be excreted in breast milk. Consult a doctor before use, especially during prolonged or extensive application.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, drugstores, supermarkets, hospitals
Approval Status
Generally approved by major regulatory bodies (e.g., FDA, EMA, DGDA) for OTC use.
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Povidone-Iodine has been extensively studied for its antiseptic properties since its introduction. Numerous clinical trials confirm its efficacy and safety in wound disinfection and surgical antisepsis. Ongoing research explores its role in broader infection control and specific wound healing scenarios.
Lab Monitoring
- Thyroid function tests (TSH, T3, T4) if used extensively or in patients with pre-existing thyroid conditions.
- Renal function tests if systemic absorption is suspected.
Doctor Notes
- Advise patients on proper wound cleaning before application.
- Monitor thyroid function in patients with pre-existing thyroid conditions or those requiring extensive/prolonged use.
- Emphasize external use only and avoidance of ingestion.
Patient Guidelines
- For external use only. Do not swallow.
- Avoid contact with eyes, mouth, and mucous membranes. If contact occurs, rinse thoroughly with water.
- Discontinue use and consult a doctor if irritation or infection persists or worsens.
- Do not use for more than 1 week unless directed by a doctor.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. Do not apply a double dose to make up for a missed one.
Driving Precautions
Not applicable as topical Povidone-Iodine does not cause systemic effects that impair driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene practices for wound care.
- Keep wounds clean and dry.
- Avoid tight clothing over wounds to allow air circulation.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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