Asivert
Generic Name
Betahistine
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| asivert 25 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Asivert (Betahistine) is a medication used to treat symptoms of Meniere's disease, such as vertigo (dizziness), tinnitus (ringing in the ears), and hearing loss.
Uses & Indications
Dosage
Adults
Typically 8-16 mg three times daily, or 24 mg twice daily. For 25 mg tablets, usually 25 mg two to three times daily, adjusted according to individual response.
Elderly
No specific dosage adjustment is generally required, but caution is advised in elderly patients due to potential age-related organ function decline.
Renal_impairment
No specific dosage adjustment guidelines are available; use with caution and monitor patient response.
How to Take
Take orally, preferably with or after meals to minimize gastrointestinal discomfort.
Mechanism of Action
Betahistine acts as a weak histamine H1-receptor agonist and a potent histamine H3-receptor antagonist. It is believed to increase blood flow to the inner ear and reduce endolymphatic pressure, thereby improving symptoms of Meniere's disease.
Pharmacokinetics
Onset
Therapeutic effects are gradual and may take several weeks to become noticeable.
Excretion
Primarily excreted in the urine as metabolites (mainly 2-PCA) within 24 hours.
Half life
The elimination half-life of its main metabolite (2-oxo-pyridylacetic acid) is approximately 3-4 hours.
Absorption
Rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are reached within approximately 1 hour.
Metabolism
Rapidly and almost completely metabolized via first-pass metabolism in the liver to 2-oxo-pyridylacetic acid (2-PCA).
Side Effects
Contraindications
- Known hypersensitivity to betahistine or any component of the formulation
- Pheochromocytoma (a rare tumor of the adrenal gland)
Drug Interactions
Antihistamines
May antagonize the effects of betahistine.
MAO Inhibitors
May increase the exposure to betahistine.
Beta-2 Agonists
There are theoretical reports of a possible interaction with beta-2 agonists, but no formal studies.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, and convulsions (at very high doses). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy or lactation unless the potential benefits outweigh the potential risks. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Betahistine has been extensively studied in clinical trials for Meniere's disease and related vestibular disorders. Ongoing research continues to explore its efficacy and potential new applications.
Lab Monitoring
- Routine laboratory monitoring is generally not required for betahistine treatment.
Doctor Notes
- Advise patients that the full therapeutic effect may take several weeks to manifest, emphasizing the importance of adherence.
- Exercise caution in patients with a history of bronchial asthma or peptic ulcer due to potential worsening of conditions.
- Reassure patients about managing Meniere's symptoms with lifestyle modifications in addition to medication.
Patient Guidelines
- Take the medicine regularly as prescribed, even if symptoms improve.
- Do not stop taking the medicine abruptly without consulting your doctor.
- It may take several weeks to see the full benefits of the treatment.
- Avoid driving or operating heavy machinery if you experience dizziness or drowsiness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Betahistine may cause dizziness or drowsiness in some individuals, particularly at the start of treatment. Patients should be advised to exercise caution when driving or operating machinery.
Lifestyle Advice
- For Meniere's disease, consider reducing salt intake, avoiding caffeine and alcohol, and managing stress.
- Maintain a regular sleep schedule.
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Global Brand Names
International brand names for this medicine
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