Medicine Information

Axlovir

Name: Axlovir
Brand: Axlovir
Rating: 4.5 (117 reviews)

Tablet150 mgAntivirals (Direct-acting)ATC: J05AP01

Generic Name

Axlovir-150-mg-tablet

Manufacturer

Globex Pharmaceuticals Inc.

Country

USA

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
axlovir 150 mg tablet	৳ 1,600.00	N/A

Description

Overview of the medicine

Axlovir 150 mg Tablet is an antiviral medication used for the treatment of certain severe viral infections. It works by inhibiting the replication of the virus, thereby helping the immune system to clear the infection. It is prescribed for a limited duration.

Uses & Indications

Treatment of severe acute viral respiratory infections in adults.

Prophylaxis of viral infections in high-risk individuals.

Adjunctive therapy for certain persistent viral conditions.

Dosage

Adults

150 mg orally twice daily for 5-7 days, depending on the severity of infection.

Elderly

No specific dose adjustment is required for elderly patients unless renal impairment is present.

Renal_impairment

For creatinine clearance (CrCl) 30-50 mL/min: 150 mg once daily. For CrCl <30 mL/min: Not recommended or use with extreme caution.

How to Take

Take the tablet orally with a glass of water, with or without food. It is important to complete the full course of treatment as prescribed.

Mechanism of Action

Axlovir selectively inhibits the viral RNA-dependent RNA polymerase (RdRp), which is essential for viral replication. By binding to the active site of RdRp, it prevents the synthesis of new viral RNA strands, effectively halting viral proliferation.

Pharmacokinetics

Onset

Clinical improvement typically observed within 2-3 days of initiation of therapy.

Excretion

Excreted predominantly via urine (60-70%) as metabolites, with some fecal excretion (20-30%).

Half life

Elimination half-life is approximately 6-8 hours.

Absorption

Rapidly absorbed after oral administration, peak plasma concentrations reached within 1-2 hours. Bioavailability is approximately 80%.

Metabolism

Primarily metabolized in the liver via CYP3A4 pathway to an active metabolite.

Side Effects

Contraindications

Hypersensitivity to Axlovir or any components of the tablet.
Severe hepatic impairment.

Drug Interactions

Warfarin

May increase anticoagulant effect; monitor INR closely.

CYP3A4 Inducers (e.g., Rifampin, Phenytoin)

May decrease Axlovir plasma levels, reducing efficacy.

CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)

May increase Axlovir plasma levels, increasing risk of side effects.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote. Hemodialysis is unlikely to be effective due to high protein binding.

Pregnancy & Lactation

Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is not known if Axlovir is excreted in human milk; caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 Tablets/Blister, 2 Blisters/Box (20 Tablets)7 Tablets/Blister, 1 Blister/Box (7 Tablets)

Shelf Life

36 months from the date of manufacture.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory bodies (e.g., FDA, DGDA)

Patent Status

Patented

Clinical Trials

Phase III clinical trials demonstrated significant reduction in viral load and improved recovery rates compared to placebo in adults with moderate to severe viral infections. Further studies are ongoing to evaluate long-term safety and efficacy.

Lab Monitoring

Liver function tests (ALT, AST) before and during treatment.
Renal function tests (Creatinine, BUN) periodically.
Viral load measurements to assess treatment response.

Doctor Notes

Emphasize adherence to the full treatment course.
Monitor liver function tests, especially in patients with pre-existing hepatic conditions.
Advise patients on potential drug interactions.

Patient Guidelines

Complete the entire course of medication, even if symptoms improve.
Do not share this medication with others.
Report any severe or persistent side effects to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.