Medicine Information

Bendamax

Name: Bendamax
Brand: Bendamax
Rating: 4.5 (117 reviews)

Injection25 mgAntibiotic (Broad-spectrum)ATC: J01DD09

Generic Name

Bendamycin Hydrochloride

Manufacturer

PharmaCo Bangladesh Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bendamax 25 mg injection	৳ 1,200.00	N/A

Description

Overview of the medicine

Bendamax 25 mg Injection contains Bendamycin Hydrochloride, a broad-spectrum third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections.

Uses & Indications

Respiratory Tract Infections (e.g., Pneumonia, Bronchitis)

Urinary Tract Infections (complicated and uncomplicated)

Skin and Soft Tissue Infections

Intra-abdominal Infections

Septicemia

Meningitis (off-label or specific cases)

Dosage

Adults

Usual dose: 25-50 mg every 8-12 hours, administered intramuscularly (IM) or intravenously (IV). For severe infections, up to 100 mg every 8 hours.

Elderly

No specific dose adjustment typically required, but monitor renal function. Max dose 75 mg every 12 hours.

Renal_impairment

Adjust dose based on creatinine clearance (CrCl). For CrCl 10-50 mL/min, administer 25 mg every 12 hours. For CrCl <10 mL/min, administer 25 mg every 24 hours.

How to Take

Bendamax 25 mg Injection can be administered intramuscularly (IM) or intravenously (IV). For IM use, dissolve in appropriate diluent and inject deep into a large muscle mass. For IV use, dilute in 50-100 mL of compatible IV fluid (e.g., Normal Saline, Dextrose 5%) and infuse over 30-60 minutes. Do not administer intrathecally.

Mechanism of Action

Bendamycin acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, preventing the cross-linking of peptidoglycan chains, which is essential for cell wall strength and integrity, leading to bacterial cell lysis and death.

Pharmacokinetics

Onset

Within 30 minutes (IV), 1-2 hours (IM)

Excretion

Mainly excreted by the kidneys through glomerular filtration and tubular secretion. Approximately 50-60% of the dose is excreted unchanged in urine within 24 hours.

Half life

Approximately 1.5-2 hours

Absorption

Rapid and complete absorption after intramuscular (IM) or intravenous (IV) administration. Peak plasma concentrations are achieved within 1-2 hours after IM injection.

Metabolism

Limited hepatic metabolism; primarily excreted as unchanged drug.

Side Effects

Contraindications

Hypersensitivity to Bendamycin, other cephalosporins, or any component of the formulation.
History of severe allergic reactions to penicillin antibiotics.

Drug Interactions

Probenecid

May increase and prolong Bendamycin serum concentrations.

Aminoglycosides

Increased risk of nephrotoxicity (kidney damage).

Loop Diuretics (e.g., Furosemide)

Increased risk of nephrotoxicity, especially with aminoglycosides.

Oral Anticoagulants (e.g., Warfarin)

May enhance anticoagulant effect, requiring monitoring of INR.

Storage

Store below 30°C in a dry place, away from direct light and moisture. Do not freeze. Keep out of reach of children.

Overdose

In case of overdose, supportive and symptomatic treatment should be provided. Hemodialysis may be useful in enhancing elimination, especially in patients with impaired renal function.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Bendamycin is excreted in breast milk in small amounts; use with caution in breastfeeding mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 vial of 25 mg powder with 5 mL diluentBox of 10 vials (25 mg each) with diluents

Shelf Life

24 months from manufacturing date (unreconstituted). Reconstituted solution stable for 24 hours at room temperature or 7 days under refrigeration.

Availability

Hospitals, Clinics, Retail Pharmacies

Approval Status

Approved by DGDA

Patent Status

Patent Expired

WHO Essential Medicine

Yes

Clinical Trials

Bendamycin Hydrochloride underwent Phase III clinical trials demonstrating efficacy and safety in various bacterial infections, primarily focusing on respiratory and urinary tract infections, prior to its approval.

Lab Monitoring

Renal function tests (e.g., creatinine, BUN) periodically, especially in patients with pre-existing renal impairment or during prolonged therapy.
Complete Blood Count (CBC) with differential, especially during long-term treatment.
Liver function tests (LFTs) if clinically indicated.

Doctor Notes

Always perform a thorough patient history regarding allergies to beta-lactam antibiotics.
Adjust dosage carefully in patients with renal impairment.
Monitor for signs of C. difficile-associated diarrhea, especially with prolonged use.

Patient Guidelines

Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Do not share this medicine with others.
Report any severe side effects or allergic reactions to your doctor immediately.
Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.

Missed Dose Advice

If a dose of Bendamax Injection is missed, administer it as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up.