Medicine Information

Benfloxin

Name: Benfloxin
Brand: Benfloxin
Rating: 4.5 (117 reviews)

Tablet500 mgAntibiotic (Fluoroquinolone)ATC: J01MA

Generic Name

Benfloxin

Manufacturer

MediCorp Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
benfloxin 500 mg tablet	৳ 17.00	৳ 170.00

Description

Overview of the medicine

Benfloxin 500 mg Tablet is a broad-spectrum fluoroquinolone antibiotic used to treat a variety of bacterial infections.

Uses & Indications

Urinary Tract Infections (UTIs)

Respiratory Tract Infections (RTIs)

Skin and Soft Tissue Infections (SSTIs)

Gastrointestinal Infections

Bone and Joint Infections

Dosage

Adults

Usually 500 mg once daily or 250 mg twice daily, depending on the type and severity of infection. Duration varies from 7-14 days.

Elderly

No specific dose adjustment is required solely based on age; however, renal function should be assessed and dose adjusted if needed.

Renal_impairment

Dosage must be adjusted based on creatinine clearance. For CrCl 30-60 mL/min, 250 mg once daily; for CrCl <30 mL/min, 250 mg every 48 hours.

How to Take

Benfloxin 500 mg Tablet should be swallowed whole with a glass of water, with or without food. Do not crush, chew, or break the tablet.

Mechanism of Action

Benfloxin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes necessary for DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.

Pharmacokinetics

Onset

1-2 hours

Excretion

Primarily excreted renally via glomerular filtration and tubular secretion, both as unchanged drug and metabolites.

Half life

Approximately 8-10 hours

Absorption

Rapidly and well absorbed from the gastrointestinal tract after oral administration, with bioavailability typically around 70-80%.

Metabolism

Undergoes limited hepatic metabolism; main metabolites are active.

Side Effects

Contraindications

Hypersensitivity to benfloxin or other fluoroquinolones
History of tendinitis or tendon rupture associated with fluoroquinolone use
Children and adolescents below 18 years of age (due to risk of joint/cartilage damage)
Pregnancy and breastfeeding

Drug Interactions

NSAIDs

May increase the risk of CNS stimulation and convulsions.

Warfarin

May enhance anticoagulant effects; monitor INR closely.

Theophylline

May increase theophylline levels and risk of toxicity.

Antacids/Iron/Zinc/Sucralfate

May reduce absorption of benfloxin; administer benfloxin 2 hours before or 4-6 hours after these agents.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be considered. Symptomatic and supportive treatment should be initiated. Monitor ECG due to potential for QT prolongation.

Pregnancy & Lactation

Benfloxin is generally contraindicated during pregnancy and breastfeeding due to potential risks to fetal cartilage development and excretion into breast milk. Consult a doctor for alternative treatments.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 Tablets (blister pack)20 Tablets (blister pack)

Shelf Life

36 months from the date of manufacture

Availability

Available in pharmacies, hospitals, and clinics

Approval Status

Approved by regulatory authorities (e.g., DGDA)

Patent Status

Generic; Patent expired

WHO Essential Medicine

Yes

Clinical Trials

Benfloxin has undergone standard clinical trials demonstrating its efficacy and safety profile for approved indications, with studies often comparing it to other established fluoroquinolones.

Lab Monitoring

Renal function tests (creatinine, BUN)
Liver function tests (ALT, AST, ALP)
Blood glucose levels (especially in diabetic patients)
INR (for patients on warfarin)

Doctor Notes

Advise patients to report any tendon pain or weakness immediately.
Emphasize completing the full course of therapy.
Counsel on potential CNS effects and photosensitivity.

Patient Guidelines

Complete the entire prescribed course of treatment, even if you feel better.
Drink plenty of fluids while taking this medication.
Avoid prolonged exposure to sunlight and use protective clothing/sunscreen due to photosensitivity.
Report any pain, swelling, or inflammation of tendons immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.

Driving Precautions

Benfloxin may cause dizziness or lightheadedness, affecting your ability to drive or operate machinery. Exercise caution until you know how the medication affects you.