Medicine Information

Bihale

Name: Bihale
Brand: Bihale
Rating: 4.5 (117 reviews)

Inhalation Capsule25 mcgBronchodilator, Long-acting Beta2-Adrenergic Agonist (LABA)ATC: R03AC13

Generic Name

bihale-25-mcg-inhalation-capsule

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bihale 25 mcg inhalation capsule	৳ 22.00	৳ 220.00

Description

Overview of the medicine

Bihale 25 mcg Inhalation Capsule contains Indacaterol, a long-acting beta2-agonist (LABA), used for the maintenance treatment of chronic obstructive pulmonary disease (COPD). It helps relax the muscles around the airways, making it easier to breathe.

Uses & Indications

Maintenance bronchodilator treatment for chronic obstructive pulmonary disease (COPD)

Relief of symptoms associated with COPD

Dosage

Adults

1 inhalation of 25 mcg once daily, using a dry powder inhaler device.

Elderly

No dosage adjustment required.

Renal_impairment

No dosage adjustment required.

How to Take

The capsule should be placed in a specific dry powder inhaler device (e.g., Breezhaler or similar) and inhaled. Do not swallow the capsule.

Mechanism of Action

Indacaterol is a selective long-acting beta2-adrenergic agonist (LABA). It stimulates beta2-adrenergic receptors in the smooth muscle of the lung, leading to bronchodilation. This effect is sustained for at least 24 hours.

Pharmacokinetics

Onset

Within 5 minutes.

Excretion

Primarily via feces (90%), with a minor portion excreted renally (10%).

Half life

Terminal half-life is 40-52 hours, reflecting slow release from the lung.

Absorption

Rapidly absorbed after inhalation, reaching peak plasma concentration within 15-30 minutes. Absolute bioavailability is approximately 43%.

Metabolism

Primarily hepatic, via hydroxylation by UGT1A1 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to indacaterol or any excipients
Acute bronchospasm (not for rescue therapy)

Drug Interactions

Beta-blockers

May reduce or antagonize the effect of indacaterol.

QT-prolonging drugs

Increased risk of ventricular arrhythmias.

Other sympathomimetics

May potentiate adverse effects.

Storage

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Overdose

Symptoms include tachycardia, tremors, palpitations, headache, and nausea. Treatment is symptomatic and supportive.

Pregnancy & Lactation

Use only if the potential benefit justifies the potential risk to the fetus/infant. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per pack

Shelf Life

24 months

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Patent expired, generic versions available

Clinical Trials

Extensive clinical trials (e.g., IGNITE program) demonstrated efficacy and safety in COPD patients.

Lab Monitoring

Not routinely required. Monitor for worsening COPD symptoms.

Doctor Notes

Emphasize proper inhaler technique for optimal drug delivery.
Not for acute relief; patients should have a rescue inhaler.

Patient Guidelines

Do not use for acute breathing problems.
Use regularly, even if you feel better.
Proper inhaler technique is crucial for effectiveness.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a forgotten dose.