Medicine Information

Brodil-Levo

Name: Brodil-Levo
Brand: Brodil-Levo
Rating: 4.5 (117 reviews)

Tablet1 mgAntihistamineATC: R06AE09

Generic Name

Levocetirizine Dihydrochloride

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
brodil levo 1 mg tablet	৳ 1.10	৳ 11.00

Description

Overview of the medicine

Brodil-Levo 1 mg Tablet is an antihistamine used to relieve symptoms of allergies such as watery eyes, runny nose, itching eyes/nose, and sneezing. It is also used to relieve itching and rashes in chronic urticaria.

Uses & Indications

Seasonal and perennial allergic rhinitis

Chronic idiopathic urticaria

Allergic conjunctivitis

Other allergic conditions where antihistamines are indicated

Dosage

Adults

Typical adult dose is 5 mg once daily. For 1 mg tablet, dose should be as directed by physician, usually 1 to 5 tablets daily.

Elderly

A dose adjustment may be necessary in elderly patients with impaired renal function. Start with a lower dose.

Renal_impairment

Dose adjustment is required based on creatinine clearance. For mild impairment: 2.5 mg every other day. Moderate: 2.5 mg twice weekly. Severe: Contraindicated.

How to Take

Take Brodil-Levo 1 mg Tablet orally with or without food, usually once daily in the evening. Swallow the tablet whole with a glass of water.

Mechanism of Action

Levocetirizine, the active ingredient, selectively blocks histamine H1 receptors. This prevents histamine, a substance released during allergic reactions, from binding to its receptors and causing allergy symptoms.

Pharmacokinetics

Onset

Onset of action typically occurs within 1 hour.

Excretion

Excreted primarily via the kidneys (approximately 85.4% of the dose) in urine and feces (12.9%).

Half life

Plasma elimination half-life is approximately 7-10 hours in healthy adults.

Absorption

Rapidly and extensively absorbed after oral administration, reaching peak plasma concentrations within 0.9-1.3 hours.

Metabolism

Less than 14% of the dose is metabolized, primarily by aromatic oxidation, N- and O-dealkylation, and taurine conjugation. It is not extensively metabolized by the liver.

Side Effects

Contraindications

Hypersensitivity to levocetirizine or any other piperazine derivatives
Patients with severe renal impairment (creatinine clearance less than 10 mL/min)
Patients on hemodialysis
Infants less than 6 months of age

Drug Interactions

Ritonavir

May increase plasma concentrations of levocetirizine and extend its half-life, potentially increasing adverse effects.

Theophylline

May slightly decrease the clearance of levocetirizine, but this interaction is generally not clinically significant.

CNS Depressants (e.g., alcohol, sedatives)

Concurrent use may increase CNS depression (drowsiness, impaired cognitive function).

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include drowsiness in adults and agitation or restlessness followed by drowsiness in children. Treatment is supportive and symptomatic; there is no specific antidote. Gastric lavage may be considered soon after ingestion.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate human studies. Use only if clearly needed. Levocetirizine is excreted in breast milk; consult a doctor before breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box (3 strips of 10)

Shelf Life

24 to 36 months from the date of manufacture, depending on storage conditions.

Availability

Available in pharmacies nationwide

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Levocetirizine has undergone numerous clinical trials demonstrating its efficacy and safety for allergic rhinitis and chronic idiopathic urticaria.

Lab Monitoring

No routine laboratory monitoring is typically required for levocetirizine. Renal function should be monitored in patients with pre-existing renal impairment.

Doctor Notes

Advise patients about potential for drowsiness and caution regarding driving/operating machinery.
Consider dose adjustment in elderly patients and those with renal impairment.
Review patient's medication history for potential drug interactions, especially with CNS depressants.

Patient Guidelines

Do not exceed the recommended dose.
Avoid alcohol while taking this medicine, as it may increase drowsiness.
If symptoms persist or worsen, consult your doctor.
Store this medicine out of the reach and sight of children.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Brodil-Levo may cause drowsiness, dizziness, or impaired vision. Exercise caution when driving or operating machinery until you know how the medicine affects you.

Lifestyle Advice

Identify and avoid known allergens to minimize exposure.
Maintain good hygiene to prevent allergic triggers.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Neoceptin R (Incepta Pharmaceuticals Ltd.)L-Cetin (Beximco Pharmaceuticals Ltd.)Cetzine (Square Pharmaceuticals Ltd.) - containing Cetirizine, a related drugLevosiz (Ziska Pharmaceuticals Ltd.)