Brozep
Generic Name
Bromazepam
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
brozep 3 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Brozep 3 mg Tablet contains Bromazepam, which is a benzodiazepine used to treat anxiety disorders, panic attacks, and occasionally, insomnia when associated with anxiety. It works by affecting brain chemicals that may be unbalanced in people with anxiety.
Uses & Indications
Dosage
Adults
Usually 3 mg to 18 mg daily, divided into 2 or 3 doses. In severe cases, up to 30 mg daily. For insomnia, 3-6 mg at bedtime.
Elderly
Initiate with lower doses, e.g., 1.5 mg to 3 mg daily, divided doses, due to increased sensitivity and slower elimination.
Renal_impairment
Use with caution; dose reduction may be necessary. Start with lower doses.
How to Take
Take orally with or without food. Do not chew or crush the tablet; swallow whole with water. Avoid alcohol.
Mechanism of Action
Bromazepam acts on the central nervous system to enhance the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits nerve activity. This leads to sedative, anxiolytic, muscle relaxant, and anticonvulsant properties.
Pharmacokinetics
Onset
Approximately 30-60 minutes.
Excretion
Excreted mainly in urine as metabolites.
Half life
10-20 hours (intermediate-acting benzodiazepine).
Absorption
Well absorbed after oral administration; peak plasma concentrations reached in 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4, to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to bromazepam or other benzodiazepines
- Severe respiratory insufficiency
- Severe hepatic insufficiency
- Sleep apnea syndrome
- Myasthenia gravis
Drug Interactions
Antacids
May delay absorption but do not affect extent.
CNS depressants (alcohol, opioids, antidepressants)
Increased risk of sedation, respiratory depression.
CYP3A4 inhibitors (e.g., ketoconazole, fluvoxamine)
May increase bromazepam levels, leading to enhanced effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, confusion, ataxia, diminished reflexes, and coma. Management involves supportive care, maintaining airway, monitoring vital signs. Flumazenil may be used in severe cases but carries risks of withdrawal seizures.
Pregnancy & Lactation
Pregnancy Category D: May cause fetal harm. Avoid during pregnancy, especially in the first trimester and near term, due to risk of congenital malformations and neonatal withdrawal symptoms. Excreted into breast milk; not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 24 to 36 months from the date of manufacture.
Availability
Pharmacies
Approval Status
Approved (local regulatory bodies like DGDA in Bangladesh)
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have established Bromazepam's efficacy and safety in the short-term management of anxiety disorders. Ongoing research focuses on long-term effects and dependence management strategies.
Lab Monitoring
- Liver function tests (especially with long-term use or hepatic impairment).
- Renal function tests (if renal impairment is suspected).
Doctor Notes
- Prescribe for the shortest possible duration, ideally 2-4 weeks, including a tapering period.
- Educate patients about the risks of dependence, withdrawal, and interactions with alcohol/opioids.
- Monitor for signs of misuse, abuse, and dependence.
- Consider non-pharmacological therapies for anxiety as first-line.
Patient Guidelines
- Do not stop taking this medicine abruptly, as it may lead to withdrawal symptoms. Consult your doctor for gradual dose reduction.
- Avoid consuming alcohol while on this medication.
- Report any unusual or severe side effects to your doctor immediately.
- This medicine is for short-term use only, typically not exceeding 2-4 weeks.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Brozep 3 mg Tablet can cause drowsiness, dizziness, and impaired concentration. Do not drive or operate heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Practice stress reduction techniques like meditation or deep breathing.
- Maintain a regular sleep schedule and good sleep hygiene.
- Avoid caffeine and other stimulants, especially in the evening.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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