Medicine Information

Bulex

Name: Bulex
Brand: Bulex
Rating: 4.5 (117 reviews)

SyrupBromhexine HCl 4 mg + Guaifenesin 75 mg / 5 mlMucolytics & ExpectorantsATC: R05CA10

Generic Name

Bromhexine Hydrochloride + Guaifenesin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bulex 75 mg syrup	৳ 80.00	N/A

Description

Overview of the medicine

Bulex-75-mg syrup is a combination medication used to treat cough and congestion associated with various respiratory conditions. It contains a mucolytic and an expectorant.

Uses & Indications

Acute and chronic bronchitis

Asthmatic bronchitis

Bronchial asthma with difficulty in expectoration

Cough associated with common cold and flu

Dosage

Adults

Adults: 10 ml (2 teaspoonfuls) 3 times daily.

Elderly

No specific dose adjustment is required, but use with caution in those with pre-existing conditions.

Children

Children 6-12 years: 5 ml (1 teaspoonful) 3 times daily; Children 2-6 years: 2.5 ml (½ teaspoonful) 3 times daily; Below 2 years: Consult a physician.

Renal_impairment

Use with caution in severe renal impairment; dose reduction may be necessary.

How to Take

To be taken orally, with or without food. Measure dose with an accurate measuring device.

Mechanism of Action

Bromhexine thins and loosens mucus by depolymerizing mucopolysaccharide fibers. Guaifenesin increases the volume and reduces the viscosity of secretions in the trachea and bronchi, thereby facilitating the removal of phlegm.

Pharmacokinetics

Onset

Bromhexine: Approx. 30 minutes; Guaifenesin: Approx. 30 minutes

Excretion

Bromhexine and its metabolites are primarily excreted via the kidneys. Guaifenesin and its metabolites are excreted via the kidneys.

Half life

Bromhexine: 15-20 hours (terminal); Guaifenesin: Approx. 1 hour

Absorption

Bromhexine is rapidly and almost completely absorbed from the GI tract. Guaifenesin is rapidly absorbed from the GI tract.

Metabolism

Bromhexine undergoes extensive first-pass metabolism in the liver. Guaifenesin undergoes rapid metabolism.

Side Effects

Contraindications

Hypersensitivity to Bromhexine, Guaifenesin, or any component of the formulation
Gastric ulcer (relative contraindication for Bromhexine due to potential gastric irritation)

Drug Interactions

Antibiotics

Bromhexine may increase penetration of certain antibiotics (e.g., amoxicillin, erythromycin) into bronchial secretions.

Antitussives

Concurrent use with antitussives (cough suppressants) is not recommended as it may lead to accumulation of secretions due to suppression of cough reflex.

Storage

Store below 30°C in a dry place, away from light. Keep out of reach of children.

Overdose

Symptoms may include nausea, vomiting, diarrhea, and gastric irritation. Treatment is symptomatic and supportive. Gastric lavage may be considered.

Pregnancy & Lactation

Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Caution advised during lactation as components may be excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 ml syrup bottle200 ml syrup bottle

Shelf Life

36 months

Availability

Pharmacies, Hospitals

Approval Status

Approved by DGDA/FDA

Patent Status

Generic

WHO Essential Medicine

Yes

Clinical Trials

As a generic combination, extensive new clinical trials are generally not required, relying on established efficacy and safety data of individual components.

Lab Monitoring

No routine lab monitoring is generally required.

Doctor Notes

Advise patients to report any severe skin reactions immediately.
Monitor for signs of gastric irritation in susceptible patients.
Emphasize adequate fluid intake.

Patient Guidelines

Do not exceed the recommended dose.
Consult a doctor if symptoms persist for more than 7 days or worsen.
Drink plenty of fluids to help loosen mucus.

Missed Dose Advice

If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.

Driving Precautions

May cause dizziness in some individuals, so caution should be exercised when driving or operating machinery.

Lifestyle Advice

Stay hydrated by drinking plenty of water.
Avoid smoking and exposure to irritants that may worsen cough.
Maintain good hygiene to prevent spread of respiratory infections.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Brofex Syrup (Acme Laboratories)Expectomin Syrup (Incepta Pharmaceuticals)Mucosol Syrup (Renata Limited)

Global Brand Names

International brand names for this medicine

Bisolvon (Bromhexine - Germany, Australia, etc.)Robitussin Mucus & Chest Congestion (Guaifenesin - USA, UK)Sputolysin (Bromhexine - various countries)