Medicine Information

Calcibost-D

Name: Calcibost-D
Brand: Calcibost-D
Rating: 4.5 (117 reviews)

TabletCalcium Carbonate 1250 mg (equivalent to 500 mg elemental Calcium) + Cholecalciferol (Vitamin D3) 200 IUMineral & Vitamin SupplementsATC: A12AX

Generic Name

Calcium Carbonate + Cholecalciferol (Vitamin D3)

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
calcibost d 500 mg tablet	৳ 7.00	N/A

Description

Overview of the medicine

Calcibost-D 500 mg tablet is a combination supplement containing Calcium Carbonate and Vitamin D3. It is primarily used to maintain healthy bones and teeth, and for the prevention and treatment of calcium and Vitamin D deficiencies.

Uses & Indications

Prevention and treatment of osteoporosis (postmenopausal, senile, steroid-induced)

Calcium and Vitamin D deficiency states

As a supplement during pregnancy and lactation

Hypocalcemia, latent tetany

Rickets and osteomalacia

Dosage

Adults

Usually 1-2 tablets daily, or as directed by physician. May be taken in divided doses.

Elderly

Same as adult dosage, but caution with renal function. Consult physician.

Renal_impairment

Use with caution. Dosage adjustment may be required based on serum calcium and phosphate levels. Contraindicated in severe renal impairment.

How to Take

Oral administration. Tablets can be taken with or without food, but generally recommended to be taken with food for better absorption and to minimize gastrointestinal upset. Do not exceed the recommended dose.

Mechanism of Action

Calcium is an essential mineral required for bone formation, nerve impulse transmission, muscle contraction, and blood coagulation. Vitamin D3 (Cholecalciferol) helps regulate calcium and phosphate homeostasis, facilitating their absorption from the gut and deposition into bone. It also plays a role in immune function.

Pharmacokinetics

Onset

Therapeutic effects on bone density are gradual and require consistent intake over several weeks to months.

Excretion

Unabsorbed calcium is excreted in feces. Absorbed calcium is excreted primarily via kidneys. Vitamin D3 metabolites are excreted mainly in bile and feces, with a small amount in urine.

Half life

Elemental Calcium has a relatively short half-life in blood, but its biological half-life in bone is much longer. Vitamin D3 has a half-life of about 15-20 hours, but its active metabolite calcitriol has a longer half-life.

Absorption

Calcium absorption is variable and depends on factors like age, Vitamin D status, and dietary intake. Vitamin D3 is well absorbed from the gastrointestinal tract, primarily in the small intestine.

Metabolism

Calcium is not metabolized. Vitamin D3 is hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol) and then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol), its active form.

Side Effects

Contraindications

Hypersensitivity to Calcium Carbonate, Vitamin D3, or any component of the formulation
Hypercalcemia (high levels of calcium in blood)
Hypercalciuria (high levels of calcium in urine)
Severe renal impairment
Hypervitaminosis D

Drug Interactions

Digoxin

Hypercalcemia can increase the risk of digoxin toxicity. Monitor closely.

Levothyroxine

Calcium may impair absorption. Separate administration by at least 4 hours.

Bisphosphonates

Calcium can interfere with bisphosphonate absorption. Administer calcium at least 30 minutes after bisphosphonates.

Thiazide diuretics

May reduce calcium excretion, increasing the risk of hypercalcemia.

Tetracycline and Fluoroquinolone antibiotics

Calcium can reduce the absorption of these antibiotics. Administer at least 2 hours before or 4-6 hours after calcium supplements.

Storage

Store in a cool, dry place, away from direct light and moisture, below 30°C. Keep out of reach of children.

Overdose

Symptoms of overdose include hypercalcemia (nausea, vomiting, constipation, thirst, polyuria, muscle weakness, confusion, kidney stones). In severe cases, cardiac arrhythmias may occur. Treatment involves discontinuing the supplement, hydration, and medical management to lower calcium levels.

Pregnancy & Lactation

Generally considered safe and often recommended during pregnancy and lactation to meet increased calcium and Vitamin D requirements. However, always consult a healthcare professional before use. Excessive doses should be avoided.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets (3x10's blister pack)60 tablets (6x10's blister pack)100 tablets (bottle)

Shelf Life

2-3 years from the date of manufacture, depending on manufacturer specifications.

Availability

Pharmacies, drugstores

Approval Status

Approved by health authorities

Patent Status

Off-patent

Clinical Trials

Numerous clinical trials support the efficacy of calcium and Vitamin D supplementation in improving bone mineral density, reducing fracture risk in at-risk populations, and treating deficiency states. Specific trials for Calcibost-D would be conducted by the manufacturer for regulatory approval.

Lab Monitoring

Serum calcium levels (especially in patients with renal impairment or on long-term therapy)
Serum Vitamin D levels (25-hydroxyvitamin D)
Renal function (creatinine, eGFR) in at-risk patients

Doctor Notes

Assess patient's dietary calcium and Vitamin D intake before prescribing.
Consider underlying conditions (e.g., malabsorption, renal dysfunction) that may affect calcium/Vitamin D metabolism.
Counsel patients on potential drug interactions, especially with antibiotics and thyroid hormones.
Advise on lifestyle modifications for optimal bone health.

Patient Guidelines

Take exactly as directed by your doctor or pharmacist.
Do not exceed the recommended dose.
Take with a full glass of water.
Inform your doctor about all other medications you are taking, especially antibiotics, thyroid hormones, and diuretics.
Maintain adequate fluid intake.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Calcibost-D is not expected to affect the ability to drive or operate machinery.

Lifestyle Advice

Engage in regular weight-bearing exercise to support bone health.
Maintain a balanced diet rich in calcium (e.g., dairy products, leafy greens) and Vitamin D (e.g., fatty fish, fortified foods).
Moderate sun exposure can help the body produce Vitamin D.