Medicine Information

Calfix-DX

Name: Calfix-DX
Brand: Calfix-DX
Rating: 4.5 (117 reviews)

TabletElemental Calcium 600 mg + Vitamin D3 200 IUCalcium Preparations with Vitamin DATC: A12AX

Generic Name

Calcium Carbonate + Cholecalciferol

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
calfix dx 600 mg tablet	৳ 14.00	৳ 140.00

Description

Overview of the medicine

Calfix-DX 600 mg Tablet is a combination medicine containing Calcium Carbonate and Cholecalciferol (Vitamin D3). It is primarily used to prevent or treat calcium deficiency and to support bone health by ensuring adequate calcium absorption.

Uses & Indications

Prevention and treatment of calcium deficiency states.

Osteoporosis (as an adjunct to specific therapy).

Osteomalacia and rickets (as an adjunct to specific therapy).

Increased calcium requirement during pregnancy and lactation.

Post-menopausal osteoporosis prevention.

Senile osteoporosis.

Dosage

Adults

Usually 1-2 tablets daily, or as directed by the physician.

Elderly

Same as adult dosage, but may require closer monitoring of calcium levels if there are renal concerns.

Renal_impairment

Use with caution. Dosage adjustment may be required, and serum calcium/phosphate levels should be monitored. Consult a physician.

How to Take

Take the tablet orally, preferably with or after food, with a glass of water. Do not chew or crush the tablet.

Mechanism of Action

Calcium is an essential mineral required for various physiological processes, including bone formation, muscle contraction, and nerve function. Cholecalciferol (Vitamin D3) enhances the absorption of calcium from the gastrointestinal tract and regulates calcium and phosphate levels in the body, promoting proper bone mineralization.

Pharmacokinetics

Onset

Therapeutic effects on bone density and mineral levels are gradual, typically observed over weeks to months.

Excretion

Unabsorbed calcium is excreted in feces. Absorbed calcium is excreted primarily in urine and feces. Vitamin D metabolites are excreted mainly in bile and feces.

Half life

Elemental calcium has a complex pharmacokinetic profile. Vitamin D3 (cholecalciferol) has a plasma half-life of about 19-25 hours, but its active metabolite calcitriol has a half-life of 3-6 hours. The storage form (25-hydroxyvitamin D) has a much longer half-life (several weeks).

Absorption

Calcium is absorbed from the small intestine, primarily in the duodenum. Absorption is increased by Vitamin D. Cholecalciferol is absorbed from the small intestine, mainly in the jejunum and ileum, and incorporated into chylomicrons.

Metabolism

Calcium is not metabolized in the traditional sense. Cholecalciferol is hydroxylated in the liver to 25-hydroxycholecalciferol (calcidiol), and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form.

Side Effects

Contraindications

Hypersensitivity to the active substances or any of the excipients.
Hypercalcemia (high calcium levels in blood).
Severe hypercalciuria (high calcium levels in urine).
Severe renal impairment.
Vitamin D hypervitaminosis.

Drug Interactions

Levothyroxine

Calcium may impair levothyroxine absorption. Separate administration by at least 4 hours.

Bisphosphonates

Calcium can reduce their absorption. Take calcium at least 30-60 minutes after bisphosphonates.

Cardiac Glycosides

Hypercalcemia increases the risk of digoxin toxicity.

Thiazide diuretics

May reduce renal excretion of calcium, leading to hypercalcemia.

Tetracyclines and Fluoroquinolones

Calcium can interfere with the absorption of these antibiotics. Administer at least 2-3 hours before or 4-6 hours after calcium.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of the reach of children.

Overdose

Symptoms of overdose may include hypercalcemia (nausea, vomiting, constipation, polyuria, polydipsia, muscle weakness, fatigue, confusion, kidney stones in severe cases). Management involves discontinuing the product, rehydration, and symptomatic treatment. Severe cases may require hospitalization.

Pregnancy & Lactation

Calcium and Vitamin D are essential during pregnancy and lactation. This medicine can be used during these periods under medical supervision if the benefits outweigh the potential risks and the dosage is within recommended limits. Consult your doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets (3x10's blister pack)60 tablets (6x10's blister pack)

Shelf Life

Typically 24-36 months from the date of manufacture.

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Generic

Clinical Trials

Specific clinical trials for 'Calfix-DX' are brand-specific. However, the efficacy and safety of calcium carbonate and cholecalciferol in various indications (e.g., osteoporosis, calcium deficiency) are well-established through numerous clinical trials worldwide.

Lab Monitoring

Serum calcium levels (especially in patients with renal impairment or on high doses).
Urinary calcium excretion (if hypercalciuria is suspected).
Serum phosphate levels.
Renal function (e.g., serum creatinine) in patients with long-term use or renal impairment.
Serum 25-hydroxyvitamin D levels (to assess vitamin D status).

Doctor Notes

Ensure patient understanding of proper dosage and administration.
Counsel patients on potential drug and food interactions.
Advise on lifestyle modifications that complement therapy (diet, exercise, sun exposure).
Monitor serum calcium, vitamin D levels, and renal function in patients on long-term therapy or with pre-existing conditions.
Emphasize that this is a supplement, not a sole treatment for severe underlying conditions.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor or as indicated on the label.
Do not exceed the recommended dose without consulting a healthcare professional.
Inform your doctor or pharmacist about all other medications, supplements, and herbal products you are taking.
Report any unusual or severe side effects to your doctor immediately.
Keep out of reach of children.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Calfix-DX is not known to affect the ability to drive or operate machinery.

Lifestyle Advice

Maintain a balanced diet rich in calcium (e.g., dairy products, leafy greens) and Vitamin D (e.g., fatty fish, fortified foods).
Engage in regular weight-bearing exercise to support bone health.
Ensure adequate exposure to sunlight (while practicing sun safety) for natural Vitamin D synthesis.
Avoid excessive alcohol consumption and smoking, as these can negatively impact bone density.