Cefocef
Generic Name
Cefixime 100 mg Suspension
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
cefocef 100 mg suspension | ৳ 175.00 | N/A |
Description
Overview of the medicine
Cefixime is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections including respiratory tract infections, urinary tract infections, otitis media, and gonorrhoea.
Uses & Indications
Dosage
Adults
Adults and children over 12 years or weighing more than 50 kg: 400 mg once daily or 200 mg twice daily. For suspension, dosage is adjusted by weight for children.
Elderly
No special dosage adjustment required unless renal function is severely impaired.
Renal_impairment
Dosage adjustment is necessary in patients with creatinine clearance < 60 mL/min. For CrCl 21-60 mL/min, 75% of standard dose. For CrCl < 20 mL/min, 50% of standard dose.
How to Take
Cefixime suspension is taken orally, with or without food. Shake the bottle well before each use. Measure the dose accurately using the provided measuring device.
Mechanism of Action
Cefixime works by interfering with the synthesis of the bacterial cell wall, which leads to the lysis and death of the bacterial cell. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, inhibiting the transpeptidation reaction essential for cell wall synthesis.
Pharmacokinetics
Onset
Typically within 1 hour.
Excretion
Primarily excreted unchanged in urine and bile.
Half life
About 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food slightly delays absorption but does not significantly affect the extent of absorption.
Metabolism
Not extensively metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
May increase prothrombin time, monitor INR.
Nifedipine
Increased Cefixime absorption reported.
Carbamazepine
Increased plasma levels of carbamazepine reported.
Storage
Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard any unused portion after 14 days.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Cefixime is excreted in breast milk; use with caution in nursing mothers, benefits versus risks should be considered.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 years for the un-reconstituted powder. Once reconstituted, it is usually stable for 7-14 days when stored as directed.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in treating various bacterial infections. Ongoing post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Renal function tests (e.g., creatinine, BUN) may be monitored during prolonged therapy or in patients with pre-existing renal impairment.
- Complete Blood Count (CBC) may be monitored periodically.
Doctor Notes
- Advise patients on the importance of completing the full prescribed course of treatment to prevent resistance.
- Educate on potential side effects and when to seek medical attention.
- Consider renal function for dose adjustment, especially in elderly or renally impaired patients.
Patient Guidelines
- Complete the full course of antibiotic as prescribed, even if you feel better, to prevent the development of antibiotic resistance.
- Do not skip doses or stop taking the medicine without consulting your doctor.
- Shake the suspension well before each use.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid alcohol consumption as it may worsen certain side effects.
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Global Brand Names
International brand names for this medicine
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