Medicine Information

Cyrin

Name: Cyrin
Brand: Cyrin
Rating: 4.5 (117 reviews)

Tablet10 mgAntihistamines, Appetite StimulantsATC: R06AX02

Generic Name

Cyproheptadine

Manufacturer

UniMed UniHealth

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cyrin 10 mg tablet	৳ 3.00	N/A

Description

Overview of the medicine

Cyproheptadine is an antihistamine with antiserotonergic, anticholinergic, and sedative properties. It is used to treat allergic reactions and as an appetite stimulant.

Uses & Indications

Allergic rhinitis

Perennial allergic conjunctivitis

Allergic skin manifestations (e.g., urticaria, angioedema)

Vascular headaches (e.g., migraine)

Appetite stimulation

Dosage

Adults

4 mg to 20 mg daily, usually divided into 2-3 doses. For appetite stimulation, typically 4 mg 3 times daily.

Elderly

Start with lower doses (e.g., 4 mg once or twice daily) due to increased sensitivity to anticholinergic effects.

Renal_impairment

Use with caution; dose adjustment may be necessary in severe impairment.

How to Take

Oral administration, with or without food.

Mechanism of Action

Cyproheptadine acts as a potent H1-receptor antagonist. It also has antiserotonergic activity (at 5-HT2 receptors) and anticholinergic effects, contributing to its appetite-stimulating and sedative properties.

Pharmacokinetics

Onset

Antihistaminic effects within 15-30 minutes, peak effect at 6-8 hours.

Excretion

Primarily via urine (about 2-20% as unchanged drug) and feces.

Half life

Approximately 8 hours.

Absorption

Well absorbed from the GI tract. Peak plasma levels usually reached in 1-3 hours.

Metabolism

Extensively metabolized in the liver, primarily by conjugation.

Side Effects

Contraindications

Hypersensitivity to cyproheptadine or similar drugs
Neonates or premature infants
Breastfeeding mothers
Elderly or debilitated patients (due to increased risk of anticholinergic side effects)
Angle-closure glaucoma
Stenosing peptic ulcer
Symptomatic prostatic hypertrophy
Bladder neck obstruction
Pyloroduodenal obstruction
MAO inhibitor therapy

Drug Interactions

MAO Inhibitors

Intensification and prolongation of anticholinergic effects

Anticholinergics

Additive anticholinergic effects

CNS Depressants (e.g., alcohol, sedatives, hypnotics)

Increased sedative effect

Storage

Store below 30°C, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms include CNS depression (sedation, coma) or stimulation (excitement, hallucinations), dry mouth, fixed dilated pupils, flushing, gastrointestinal symptoms. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal.

Pregnancy & Lactation

Pregnancy Category B. Not recommended during breastfeeding as it may pass into breast milk and harm the infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

Blister pack of 10 tabletsBox of 100 tablets

Shelf Life

24-36 months

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent

Clinical Trials

Extensive historical data; newer trials focus on specific off-label uses or comparisons.

Lab Monitoring

Monitor for signs of bone marrow depression (rare).

Doctor Notes

Warn patients about sedation, especially when starting treatment.
Consider anticholinergic burden in elderly patients.
Monitor weight if used for appetite stimulation.

Patient Guidelines

Take exactly as prescribed.
Do not drive or operate machinery until you know how this medicine affects you.
Avoid alcohol and other CNS depressants.
Report any unusual side effects to your doctor.

Missed Dose Advice

Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double the dose.

Driving Precautions

May cause drowsiness, dizziness, or blurred vision. Patients should be warned about engaging in activities requiring mental alertness, such as driving or operating heavy machinery.