Medicine Information

D-Gain ODT

Name: D-Gain ODT
Brand: D-Gain ODT
Rating: 4.5 (117 reviews)

Orally Disintegrating Tablet (ODT)2000 IUVitamin D preparationsATC: A11CC05

Generic Name

Cholecalciferol (Vitamin D3)

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
d gain odt 2000 iu tablet	৳ 4.00	৳ 40.00

Description

Overview of the medicine

D-Gain ODT 2000 IU Tablet contains Cholecalciferol (Vitamin D3), essential for calcium and phosphate absorption, bone health, and immune function. It's an orally disintegrating tablet, designed for easy administration by dissolving quickly in the mouth without water.

Uses & Indications

Treatment and prevention of Vitamin D deficiency

Adjunct to specific therapy for osteoporosis in patients with Vitamin D deficiency or at risk of Vitamin D deficiency

Rickets and osteomalacia

Hypoparathyroidism

Dosage

Adults

For Vitamin D deficiency, typically 2000 IU to 4000 IU daily, or higher doses intermittently, based on serum 25(OH)D levels. For maintenance, 800-2000 IU daily. Follow physician's advice.

Elderly

Similar to adult dosage; higher doses might be needed due to reduced skin synthesis and dietary intake. Follow physician's advice.

Renal_impairment

Use with caution. Active Vitamin D (calcitriol) may be preferred in severe renal impairment. Consult a physician.

How to Take

Place the orally disintegrating tablet on the tongue. It will dissolve quickly and can be swallowed with saliva. No water is required. It can be taken with or without food, but absorption may be better with a fatty meal.

Mechanism of Action

Cholecalciferol (Vitamin D3) is converted in the body to its active form, calcitriol. Calcitriol acts as a hormone to regulate calcium and phosphate homeostasis, primarily by increasing their absorption from the intestine, promoting bone mineralization, and affecting renal reabsorption and parathyroid hormone secretion.

Pharmacokinetics

Onset

Effects on calcium and phosphate levels typically seen within days to weeks of consistent supplementation.

Excretion

Mainly excreted in bile and feces, with a small amount in urine.

Half life

The elimination half-life of cholecalciferol is approximately 24 hours, but the half-life of its active metabolite, calcitriol, is about 3-6 hours. Stored Vitamin D has a much longer functional half-life.

Absorption

Readily absorbed from the small intestine, primarily in the presence of bile salts and dietary fat.

Metabolism

Hydroxylated in the liver to 25-hydroxyvitamin D3 (calcifediol) and then in the kidneys to 1,25-dihydroxyvitamin D3 (calcitriol, the active form).

Side Effects

Contraindications

Hypercalcemia (high calcium levels in blood)
Hypervitaminosis D (excessively high Vitamin D levels)
Severe renal impairment with hyperphosphatemia (high phosphate levels) in some cases.

Drug Interactions

Corticosteroids

May counteract the effects of Vitamin D.

Thiazide diuretics

May increase the risk of hypercalcemia.

Phenytoin, Barbiturates

May reduce Vitamin D activity by accelerating its metabolism.

Cholestyramine, Colestipol, Orlistat, Mineral oil

May reduce the absorption of Vitamin D.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose (hypervitaminosis D and hypercalcemia) include nausea, vomiting, loss of appetite, thirst, polyuria, constipation, muscle weakness, and fatigue. In severe cases, it can lead to kidney damage and cardiac arrhythmias. Treatment involves discontinuing Vitamin D, reducing calcium intake, and hydration.

Pregnancy & Lactation

Vitamin D is essential during pregnancy and lactation. This medicine can be used under medical supervision to maintain adequate Vitamin D levels in pregnant and breastfeeding women. Excessive doses should be avoided.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister pack30 tablets per box

Shelf Life

Usually 24-36 months from the date of manufacture, check the expiry date on the pack.

Availability

Pharmacies, drugstores, sometimes supermarkets

Approval Status

Generally approved and widely available

Patent Status

Generic available, often off-patent

WHO Essential Medicine

Yes

Clinical Trials

Cholecalciferol has been extensively studied in numerous clinical trials for its role in bone health, autoimmune diseases, cardiovascular health, and various other conditions. Ongoing research continues to explore its broader therapeutic potential.

Lab Monitoring

Serum 25(OH)D levels (to assess Vitamin D status)
Serum calcium levels
Serum phosphate levels
Renal function (creatinine, eGFR) in patients with kidney impairment or on high doses.

Doctor Notes

Assess baseline 25(OH)D levels before initiating high-dose therapy.
Monitor serum calcium and 25(OH)D levels periodically, especially during high-dose or prolonged therapy.
Consider underlying conditions (e.g., malabsorption, renal disease) that may affect Vitamin D metabolism or requirements.
Advise patients on dietary sources and safe sun exposure.

Patient Guidelines

Take exactly as directed by your doctor or pharmacist.
Do not exceed the recommended dose without medical advice.
Inform your doctor about all other medications and supplements you are taking.
Store in a cool, dry place away from direct sunlight and moisture.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

D-Gain ODT is not known to affect the ability to drive or operate machinery. However, if you experience any side effects that impair your concentration or reaction time, avoid such activities.

Lifestyle Advice

Include Vitamin D-rich foods in your diet (e.g., fatty fish, fortified milk, cereals).
Aim for moderate sun exposure (10-30 minutes, 2-3 times a week, depending on skin type and time of day) for natural Vitamin D synthesis, while being mindful of sun protection.
Engage in regular weight-bearing exercise for bone health.

Alternative Medicines in Bangladesh

Similar medicines available in the market

D-Plus ODT (Incepta Pharmaceuticals Ltd.)Vitaplex D ODT (Beximco Pharmaceuticals Ltd.)D-Cal ODT (ACI Pharmaceuticals Ltd.)Calditrol ODT (Renata Limited)