Medicine Information

Debolin

Name: Debolin
Brand: Debolin
Rating: 4.5 (117 reviews)

Tablet2000 IUVitamin D preparationsATC: A11CC05

Generic Name

Cholecalciferol (Vitamin D3)

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
debolin 2000 iu tablet	৳ 2.50	৳ 25.00

Description

Overview of the medicine

Debolin 2000 IU Tablet is a vitamin D3 supplement used to treat and prevent vitamin D deficiency, promote calcium absorption, and support bone health.

Uses & Indications

Treatment and prevention of vitamin D deficiency

Adjuvant therapy in osteoporosis

Treatment of rickets and osteomalacia

Hypoparathyroidism

Dosage

Adults

Typical maintenance dose is 2000 IU daily. For deficiency, higher doses (e.g., 4000 IU daily or weekly/monthly regimens) may be prescribed by a physician based on serum 25(OH)D levels.

Elderly

Similar to adults, but may require higher doses due to reduced skin synthesis and absorption. Individual assessment recommended.

Renal_impairment

Monitor vitamin D and calcium levels. May require activated forms of Vitamin D (e.g., calcitriol) under medical supervision, as renal conversion of cholecalciferol to calcitriol may be impaired.

How to Take

Administer orally, preferably with a meal to enhance absorption, particularly if the meal contains fat.

Mechanism of Action

Cholecalciferol is converted to its active form, calcitriol, which regulates calcium and phosphate homeostasis. It promotes absorption of calcium and phosphate from the small intestine, reabsorption of calcium in the kidneys, and plays a crucial role in bone mineralization.

Pharmacokinetics

Onset

Significant increase in serum 25(OH)D levels typically observed within days to weeks; full clinical effects may take longer.

Excretion

Primarily excreted via bile into feces; a small amount is excreted in the urine.

Half life

Cholecalciferol (unmetabolized) has a half-life of 1-2 days. The active metabolite, 25(OH)D (calcifediol), has a half-life of 2-3 weeks.

Absorption

Well absorbed from the small intestine, primarily in the presence of bile salts and dietary fat.

Metabolism

Hydroxylated in the liver to 25-hydroxyvitamin D3 (calcifediol), then further hydroxylated in the kidneys to 1,25-dihydroxyvitamin D3 (calcitriol), the active form.

Side Effects

Contraindications

Hypercalcemia (high calcium levels in blood)
Vitamin D toxicity
Hypersensitivity to cholecalciferol or any excipients of the tablet
Nephrolithiasis (kidney stones) or nephrocalcinosis (calcium deposition in kidneys)

Drug Interactions

Digoxin

Hypercalcemia caused by vitamin D may exacerbate the toxic effects of digoxin.

Corticosteroids

May reduce the effects of vitamin D by decreasing calcium absorption and increasing vitamin D metabolism.

Thiazide diuretics

May reduce urinary calcium excretion, increasing the risk of hypercalcemia.

Anticonvulsants (e.g., phenytoin, barbiturates)

May increase the metabolism of vitamin D, potentially reducing its effectiveness.

Cholestyramine, Colestipol, Orlistat, Mineral oil

May impair absorption of vitamin D.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose (hypervitaminosis D) are primarily due to hypercalcemia and may include nausea, vomiting, constipation, anorexia, polyuria, polydipsia, weakness, headache, and confusion. Severe cases can lead to kidney damage, soft tissue calcification, and cardiac arrhythmias. Management involves discontinuing vitamin D, hydration, low calcium diet, and potentially corticosteroids or bisphosphonates.

Pregnancy & Lactation

Generally considered safe at recommended daily allowances during pregnancy and lactation. Higher doses should only be used under strict medical supervision and if the potential benefit outweighs the risk. Vitamin D is essential for fetal bone development and is secreted into breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box

Shelf Life

24 months from the date of manufacture

Availability

Pharmacies, drug stores

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Generic (off-patent)

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials and studies have demonstrated the efficacy of cholecalciferol in treating and preventing vitamin D deficiency and its associated conditions. Specific trials for the 'Debolin' brand are typically bioequivalence studies.

Lab Monitoring

Serum 25(OH)D levels (to assess vitamin D status)
Serum calcium levels (to monitor for hypercalcemia)
Serum phosphate levels
Renal function tests (e.g., creatinine) with long-term high-dose therapy

Doctor Notes

Assess baseline serum 25(OH)D levels before initiating high-dose vitamin D therapy.
Monitor serum calcium, phosphate, and renal function, especially in patients receiving high doses, with pre-existing renal impairment, or on concomitant medications like thiazide diuretics.
Advise patients on appropriate sun exposure and dietary sources of vitamin D to complement supplementation.

Patient Guidelines

Take exactly as prescribed by your doctor or as indicated on the package.
Do not exceed the recommended dose without medical advice.
Inform your doctor about all other medications and supplements you are taking.
Report any symptoms of hypercalcemia (e.g., severe nausea, vomiting, unusual tiredness) to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Debolin 2000 IU Tablet is not known to affect the ability to drive or operate machinery. No special precautions are necessary.

Lifestyle Advice

Maintain a balanced diet rich in calcium and vitamin D, if possible.
Ensure adequate sun exposure, while protecting skin from excessive UV radiation.
Regular exercise can contribute to bone health.

Alternative Medicines in Bangladesh

Similar medicines available in the market

D-Vitol 2000 IU (Beximco Pharmaceuticals)Osta-D 2000 IU (Acme Laboratories)Dee-Cal 2000 IU (Aristopharma Ltd.)Vitaplex D 2000 IU (Incepta Pharmaceuticals Ltd.)