Dilator
Generic Name
Dilator
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dilator 5 mg oral solution | ৳ 35.00 | N/A |
Description
Overview of the medicine
Dilator 5 mg Oral Solution is a medication used to relax blood vessels, improving blood flow and reducing the heart's workload. It is primarily prescribed for conditions such as angina pectoris and hypertension.
Uses & Indications
Dosage
Adults
Usually 5-10 mg orally, 2-3 times daily, or as directed by physician. Dose may be titrated based on patient response.
Elderly
Lower initial dose (e.g., 2.5 mg) may be considered, with gradual titration due to increased sensitivity and potential for adverse effects.
Renal_impairment
No specific dose adjustment typically required for mild to moderate impairment; however, caution is advised in severe renal dysfunction.
How to Take
Take orally, with or without food. Measure the dose accurately using the provided measuring device.
Mechanism of Action
Dilator works by releasing nitric oxide, which activates guanylate cyclase, leading to an increase in cyclic GMP (cGMP). This results in relaxation of vascular smooth muscle cells, causing vasodilation and improved blood flow.
Pharmacokinetics
Onset
Within 15-30 minutes for oral solution.
Excretion
Mainly excreted via the kidneys as inactive metabolites.
Half life
Approximately 1-4 hours, depending on the specific dilator compound.
Absorption
Rapidly absorbed from the gastrointestinal tract. Bioavailability may vary due to first-pass metabolism.
Metabolism
Primarily hepatic metabolism, often involving glucuronidation or other pathways.
Side Effects
Contraindications
- Known hypersensitivity to Dilator or any components of the formulation
- Severe hypotension or cardiogenic shock
- Concomitant use with phosphodiesterase-5 (PDE5) inhibitors (e.g., sildenafil, tadalafil) due to risk of severe hypotension
Drug Interactions
PDE5 inhibitors
Severe hypotension and potentially fatal cardiovascular events.
Tricyclic Antidepressants
May enhance hypotensive effects.
Beta-blockers/Calcium Channel Blockers
May potentiate hypotensive effects.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypotension, tachycardia, headache, flushing, and dizziness. Management involves supportive care, elevation of legs, and if necessary, intravenous fluids or vasopressors. Contact emergency services immediately.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit outweighs the potential risk to the fetus. Caution should be exercised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date when stored unopened.
Availability
Available in pharmacies nationwide
Approval Status
Approved by Regulatory Authority
Patent Status
Generic
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Dilator in its approved indications. Further studies are ongoing to explore additional therapeutic uses.
Lab Monitoring
- Blood pressure monitoring
- Heart rate monitoring
- Renal function tests (if renal impairment suspected)
Doctor Notes
- Educate patients on potential for headache and dizziness.
- Advise patients to report any signs of severe hypotension or syncope immediately.
- Ensure patients understand the contraindication with PDE5 inhibitors.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Avoid standing up quickly to prevent dizziness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or lightheadedness, especially at the start of treatment or when changing dose. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and excessive alcohol consumption.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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