Medicine Information

Ebasten

Name: Ebasten
Brand: Ebasten
Rating: 4.5 (117 reviews)

Syrup5 mg/5 mlAntihistamine, H1 BlockerATC: R06AX22

Generic Name

Ebastine 5 mg Syrup

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ebasten 5 mg syrup	৳ 80.00	N/A

Description

Overview of the medicine

Ebastine is a non-sedating, long-acting H1-antihistamine used for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.

Uses & Indications

Symptomatic treatment of seasonal and perennial allergic rhinitis

Symptomatic treatment of chronic idiopathic urticaria

Dosage

Adults

Adults: Usually 10 mg once daily. For 5 mg syrup, 10 ml (10 mg) once daily or as advised by physician.

Elderly

No special dosage adjustment required for elderly patients with normal renal function. If renal or hepatic impairment, consult physician.

Renal_impairment

In patients with mild to moderate renal or hepatic impairment, 5 mg (5 ml syrup) once daily or as advised by physician. Caution in severe impairment.

Children_6_11_years

Children 6-11 years: 5 mg (5 ml syrup) once daily.

Children_under_6_years

Not recommended for children under 6 years.

How to Take

For oral use. Can be taken with or without food, once daily.

Mechanism of Action

Ebastine is a selective peripheral H1-receptor antagonist. It competitively inhibits the binding of histamine to H1 receptors, thereby preventing the symptoms associated with allergic reactions.

Pharmacokinetics

Onset

Onset of action within 1-3 hours.

Excretion

Excreted mainly via the urine in the form of metabolites.

Half life

The plasma elimination half-life of carebastine is 15 to 19 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract and extensively metabolized during first-pass metabolism to its active metabolite, carebastine.

Metabolism

Extensively metabolized in the liver, primarily via CYP3A4, to carebastine.

Side Effects

Contraindications

Hypersensitivity to ebastine or any of its excipients.
Patients with severe hepatic impairment.

Drug Interactions

Rifampicin

May decrease plasma levels of ebastine by inducing its metabolism, potentially reducing its efficacy.

Ketoconazole, Erythromycin, Clarithromycin

May increase plasma levels of ebastine and its active metabolite, carebastine, potentially increasing the risk of QT prolongation.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

In cases of overdose, symptomatic and supportive treatment should be given, with monitoring of vital functions and ECG for at least 24 hours.

Pregnancy & Lactation

Pregnancy Category B. Should be used during pregnancy only if clearly needed. Avoid during lactation as ebastine and its metabolite are excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

50 ml syrup bottle60 ml syrup bottle100 ml syrup bottle

Shelf Life

Typically 2-3 years from the date of manufacture when stored properly.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent

Clinical Trials

Numerous clinical trials have demonstrated the efficacy and safety of ebastine in the treatment of allergic rhinitis and chronic idiopathic urticaria, including studies in pediatric populations.

Lab Monitoring

Generally not required for routine use. Liver function tests may be considered in patients with hepatic impairment.
ECG monitoring in patients with known QT prolongation risk factors.

Doctor Notes

Monitor for potential drug interactions, especially with CYP3A4 inhibitors (e.g., azole antifungals, macrolide antibiotics) which may increase ebastine levels.
Advise patients on appropriate dosage and administration for pediatric use.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not exceed the recommended dose.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Ebastine may cause mild drowsiness in some individuals. Caution should be exercised when driving or operating machinery until you know how this medicine affects you.