Medicine Information

Edolac

Name: Edolac
Brand: Edolac
Rating: 4.5 (117 reviews)

Capsule300 mgNon-Steroidal Anti-Inflammatory Drugs (NSAIDs)ATC: M01AB16

Generic Name

edolac-300-mg-capsule

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
edolac 300 mg capsule	৳ 8.03	৳ 80.30

Description

Overview of the medicine

Edolac 300 mg Capsule contains Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. This specific 300 mg formulation is intended for once-daily dosing.

Uses & Indications

Osteoarthritis

Rheumatoid arthritis

Ankylosing spondylitis

Other painful and inflammatory conditions

Dosage

Adults

One 300 mg capsule once daily, preferably after food, or as directed by a physician. This higher strength formulation is typically for extended-release or specific indications.

Elderly

Lower doses or careful monitoring may be required. Consultation with a physician is essential due to increased risk of adverse effects.

Renal_impairment

Use with caution and at reduced doses (e.g., 100 mg/day) in mild to moderate renal impairment. Not recommended for severe renal impairment. Physician consultation is crucial.

How to Take

Swallow the capsule whole with water, preferably after a meal to minimize gastrointestinal side effects. Do not chew or crush the capsule.

Mechanism of Action

Aceclofenac exerts its anti-inflammatory, analgesic, and antipyretic effects primarily through the inhibition of prostaglandin synthesis. It achieves this by inhibiting the cyclo-oxygenase (COX) enzyme, which is involved in the conversion of arachidonic acid to prostaglandins.

Pharmacokinetics

Onset

Typically within 30-60 minutes for analgesic effects.

Excretion

Approximately two-thirds of the dose is excreted in the urine, mainly as hydroxylated metabolites, and about one-third in the feces.

Half life

Approximately 4-4.3 hours.

Absorption

Rapidly absorbed after oral administration. Oral bioavailability is approximately 100%. Peak plasma concentrations are reached within 1.25 to 3 hours.

Metabolism

Extensively metabolized in the liver, primarily by cytochrome P450 2C9 (CYP2C9), to its main metabolite, 4'-hydroxyaceclofenac.

Side Effects

Contraindications

Hypersensitivity to aceclofenac or other NSAIDs (e.g., aspirin, ibuprofen)
Active peptic ulcer or gastrointestinal bleeding
History of gastrointestinal bleeding or perforation related to previous NSAID therapy
Severe renal impairment
Severe hepatic impairment
Severe heart failure
Third trimester of pregnancy
History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs

Drug Interactions

SSRIs

Increased risk of gastrointestinal bleeding.

Lithium

Increased plasma lithium levels, potentially leading to lithium toxicity, due to reduced renal excretion of lithium.

Methotrexate

Increased plasma methotrexate levels and toxicity due to reduced renal tubular secretion of methotrexate.

Corticosteroids

Increased risk of gastrointestinal ulceration or bleeding.

Diuretics and ACE inhibitors

Reduced efficacy of antihypertensive agents; increased risk of renal impairment, especially in dehydrated patients or elderly.

Warfarin and other anticoagulants

Increased risk of bleeding due to impaired platelet function and gastrointestinal irritation. Co-administration requires careful monitoring of INR.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose with Aceclofenac may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, and rarely, diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, and convulsions. In case of suspected overdose, seek immediate medical attention. Management is primarily supportive and symptomatic. Gastric lavage and activated charcoal may be considered within an hour of ingestion.

Pregnancy & Lactation

Avoid use in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus and potential inhibition of uterine contractions. Use with caution in other trimesters only if the potential benefit outweighs the risk and under strict medical supervision. Aceclofenac is excreted in breast milk in small amounts; use with caution during lactation, and a physician's advice is recommended.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules30 capsules50 capsules

Shelf Life

24 months from the date of manufacture

Availability

Available in pharmacies, hospitals

Approval Status

Approved by regulatory authorities in various countries (e.g., DGDA in Bangladesh)

Patent Status

Generic available, original patent expired

Clinical Trials

Extensive clinical trials have established the efficacy and safety of Aceclofenac for various inflammatory conditions. Specific trials related to a 300 mg capsule formulation would be documented by the manufacturing company and accessible through regulatory bodies.

Lab Monitoring

Complete Blood Count (CBC) - for long-term use or if anemia/bleeding is suspected.
Liver function tests (LFTs) - periodically, especially with long-term therapy.
Renal function tests (e.g., serum creatinine, Blood Urea Nitrogen - BUN) - periodically, especially in elderly or patients with renal impairment risk factors.

Doctor Notes

Prioritize lowest effective dose for shortest duration consistent with individual patient treatment goals.
Monitor renal and hepatic function, and blood pressure periodically during long-term therapy, especially in elderly or at-risk patients.
Advise patients on signs and symptoms of gastrointestinal bleeding or cardiovascular events and instruct them to seek immediate medical attention if these occur.
Caution in patients with a history of cardiovascular disease, hypertension, fluid retention, or existing gastrointestinal disorders. Co-administer with a proton pump inhibitor if GI risk is high.
Review concomitant medications for potential drug interactions.

Patient Guidelines

Take the capsule exactly as prescribed by your doctor and do not exceed the recommended dose.
Take with food or milk to reduce stomach upset.
Report any signs of gastrointestinal bleeding (e.g., black, tarry stools, coffee-ground vomit) to your doctor immediately.
Avoid alcohol and other NSAIDs concurrently without consulting your doctor.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Do not use this medicine if you are pregnant (especially in the third trimester) or breastfeeding without consulting your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Edolac 300 mg Capsule may cause dizziness, drowsiness, or visual disturbances in some patients. Patients experiencing these effects should avoid driving or operating machinery.

Lifestyle Advice

Maintain a healthy lifestyle, including a balanced diet and regular exercise, as advised by your doctor, which can help manage chronic pain conditions.
Avoid smoking and limit alcohol consumption, as these can increase the risk of gastrointestinal side effects associated with NSAIDs.
Discuss appropriate pain management strategies with your healthcare provider.