Esotron
Generic Name
Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esotron 40 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Esomeprazole 40 mg is a proton pump inhibitor used to reduce the amount of acid produced in the stomach. It is prescribed for conditions like GERD, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
For GERD: 20-40 mg once daily for 4-8 weeks. For H. pylori eradication: 40 mg once daily for 10 days (in combination therapy). For Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted up to 120 mg twice daily.
Elderly
No specific dosage adjustment is generally needed based on age alone.
Renal_impairment
No dosage adjustment is typically required for patients with renal impairment.
How to Take
Take orally, swallow the tablet whole with water, at least one hour before a meal. Do not crush or chew the tablet.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that works by irreversibly blocking the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells, thereby inhibiting the final step of gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour after oral administration.
Excretion
Excreted primarily in the urine (about 80%) as metabolites, and to a lesser extent in the feces (about 20%).
Half life
Approximately 1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 64% after a single 40 mg dose, increasing to 89% with repeated once-daily administration.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and to a lesser extent by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, other substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (an antiretroviral drug).
Drug Interactions
Digoxin
Increased plasma levels of digoxin.
Warfarin
Increased INR and prothrombin time have been reported with concomitant use, requiring monitoring.
Clopidogrel
Esomeprazole may reduce the antiplatelet effect of clopidogrel by inhibiting CYP2C19.
Methotrexate
May increase methotrexate levels and/or its metabolite, especially with high doses.
Nelfinavir/Atazanavir
Significantly reduced plasma levels, leading to loss of antiviral efficacy.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Experience with esomeprazole overdose is limited. Symptoms may include gastrointestinal disturbances and weakness. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Esomeprazole is excreted in human breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Patent expired, generics available
WHO Essential Medicine
YesClinical Trials
Esomeprazole has been extensively studied in numerous clinical trials for its efficacy and safety in treating GERD, gastric ulcers, H. pylori infection, and Zollinger-Ellison syndrome.
Lab Monitoring
- For long-term use (over 1 year): Monitor Vitamin B12 levels due to potential malabsorption.
- For prolonged use: Monitor magnesium levels due to risk of hypomagnesemia.
Doctor Notes
- Consider testing for _H. pylori_ in patients with recurrent or refractory GERD symptoms.
- For long-term PPI users, periodically assess the need for continued therapy and consider lowest effective dose.
- Be aware of potential drug interactions, especially with antiplatelet agents like clopidogrel and antiretrovirals.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not crush, chew, or break the tablet; swallow it whole.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- If you experience severe or persistent side effects, contact your doctor immediately.
- Do not stop taking the medicine suddenly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Esomeprazole may cause side effects like dizziness or visual disturbances in some individuals. If you experience these, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods and drinks (e.g., spicy foods, caffeine, alcohol, fatty foods).
- Elevate the head of your bed to reduce nighttime reflux symptoms.
- Maintain a healthy weight, quit smoking, and reduce alcohol intake.
- Eat smaller, more frequent meals rather than large ones.
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