Medicine Information

Famas

Name: Famas
Brand: Famas
Rating: 4.5 (117 reviews)

Oral Suspension40 mg/5 mlH2-receptor antagonistsATC: A02BA03

Generic Name

Famotidine

Manufacturer

Square Pharmaceuticals PLC

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
famas 40 mg suspension	৳ 50.00	N/A

Description

Overview of the medicine

Famotidine is an H2-receptor antagonist used to treat and prevent ulcers in the stomach and intestines, and conditions that cause excess stomach acid, such as gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome.

Uses & Indications

Treatment of active duodenal ulcer

Treatment of active benign gastric ulcer

Treatment of gastroesophageal reflux disease (GERD)

Treatment of Zollinger-Ellison Syndrome

Prevention of recurrence of duodenal ulcer

Dosage

Adults

For active duodenal ulcer: 40 mg once daily at bedtime, or 20 mg twice daily for 4-8 weeks. For GERD: 20 mg or 40 mg twice daily for up to 12 weeks. The suspension form typically allows for flexible dosing and easier administration.

Elderly

No specific dose adjustment needed for elderly patients with normal renal function. In renal impairment, dose adjustment is necessary.

Renal_impairment

For creatinine clearance <10 mL/min, reduce the dose to 20 mg once daily or extend the dosing interval to 36-48 hours. Dose adjustments are not typically required for creatinine clearance >10 mL/min.

How to Take

Shake the bottle well before each use. Administer orally using the provided measuring device. May be taken with or without food. Follow your doctor's instructions carefully regarding duration of treatment.

Mechanism of Action

Famotidine selectively blocks histamine H2-receptors on the gastric parietal cells, leading to a significant reduction in both basal and stimulated gastric acid secretion and pepsin secretion.

Pharmacokinetics

Onset

Within 1 hour

Excretion

Primarily excreted unchanged in urine (65-70% of an intravenous dose and 25-30% of an oral dose). Renal excretion is via glomerular filtration and tubular secretion.

Half life

2.5-3.5 hours (can be prolonged in renal impairment)

Absorption

Rapidly absorbed after oral administration. Bioavailability is 40-45% and is not significantly affected by food.

Metabolism

Partially metabolized in the liver to an inactive sulfoxide metabolite. Approximately 25-30% of an oral dose is metabolized.

Side Effects

Contraindications

Hypersensitivity to famotidine or other H2-receptor antagonists (e.g., cimetidine, ranitidine, nizatidine)
Patients with acute porphyria

Drug Interactions

Antacids

Concurrent administration of antacids may decrease the absorption of famotidine. Administer famotidine 1-2 hours before antacids.

Atazanavir

Famotidine may significantly decrease plasma levels of Atazanavir, reducing its efficacy. Avoid co-administration.

Ketoconazole, Itraconazole, Cefpodoxime

Famotidine may decrease the absorption of drugs that require an acidic gastric pH for absorption by increasing gastric pH. Separate administration by at least 2 hours.

Storage

Store below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.

Overdose

Experience with famotidine overdose is limited. Symptoms may include hypotension, tachycardia, vomiting, and central nervous system (CNS) effects such as restlessness and convulsions. Treatment should be symptomatic and supportive, including gastric lavage or activated charcoal if recent ingestion. Hemodialysis may remove famotidine from the blood.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Famotidine is excreted into breast milk; caution is advised for breastfeeding mothers. Consult your doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 ml bottle100 ml bottle

Shelf Life

24 months (unopened)

Availability

Pharmacies, Hospitals

Approval Status

FDA Approved

Patent Status

Expired

WHO Essential Medicine

Yes

Clinical Trials

Famotidine has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Studies have confirmed its ability to heal ulcers, reduce GERD symptoms, and maintain remission in patients.

Lab Monitoring

No routine laboratory monitoring is typically required for healthy individuals.
Renal function should be monitored in patients with kidney impairment and dose adjusted accordingly.
Liver function tests may be considered in patients with pre-existing liver disease or those developing symptoms suggestive of hepatotoxicity.

Doctor Notes

For patients presenting with alarm symptoms (e.g., dysphagia, odynophagia, weight loss, GI bleeding), further investigation (e.g., endoscopy) is warranted before initiating H2RA therapy.
Adjust dose in renal impairment to avoid accumulation and potential adverse effects.
Counsel patients on appropriate lifestyle modifications to enhance treatment outcomes and prevent recurrence.

Patient Guidelines

Take Famas-40 mg suspension exactly as prescribed by your doctor.
Do not stop taking the medicine early, even if your symptoms improve, unless advised by your doctor.
Inform your doctor or pharmacist about all other medications, supplements, and herbal products you are taking.
Report any unusual side effects or worsening of symptoms to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Famas may cause dizziness or lightheadedness in some individuals. If you experience these effects, avoid driving or operating machinery until you know how the medicine affects you.

Lifestyle Advice

Avoid or limit consumption of foods and beverages that can trigger or worsen symptoms of acid reflux, such as spicy foods, fatty foods, caffeine, alcohol, and carbonated drinks.
Eat smaller, more frequent meals instead of large ones.
Elevate the head of your bed if you experience nighttime heartburn or reflux.
Avoid lying down immediately after eating.