Medicine Information

Fentanyl

Name: Fentanyl
Brand: Fentanyl
Rating: 4.5 (117 reviews)

Injection100 mcg/2 mLOpioid Analgesics, Anesthetics (General)ATC: N01AH01

Generic Name

Fentanyl 100 mcg Injection

Manufacturer

Various

Country

Global

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
fentanyl 100 mcg injection	৳ 40.15	N/A

Description

Overview of the medicine

Fentanyl is a potent synthetic opioid analgesic used for pain management, often in perioperative settings or for chronic severe pain, administered intravenously, intramuscularly, transdermally, or transmucosally. This specific formulation is for injection.

Uses & Indications

Analgesic adjunct in general and regional anesthesia.

Administration with droperidol as a neuroleptanalgesic.

Anesthetic premedication.

For induction and maintenance of general anesthesia.

Management of severe acute or chronic pain.

Dosage

Adults

Varies greatly depending on indication and route. For IV anesthesia, initial doses typically 2-20 mcg/kg, then incremental doses or continuous infusion. For severe pain, 50-100 mcg IV/IM every 1-2 hours as needed.

Elderly

Reduced initial doses, often by 25-50%, due to increased sensitivity and reduced clearance. Careful titration is essential.

Renal_impairment

Administer with caution. Dosage reduction may be necessary due to accumulation of metabolites and increased sensitivity. Monitor closely.

How to Take

For intravenous or intramuscular injection. Must be administered by a healthcare professional in a controlled environment due to its potency and risk of respiratory depression.

Mechanism of Action

Fentanyl is a potent mu-opioid receptor agonist. It binds to mu-opioid receptors in the central nervous system, producing analgesia, sedation, euphoria, and respiratory depression.

Pharmacokinetics

Onset

IV: 30 seconds to 1 minute; IM: 7-15 minutes.

Excretion

Primarily renal (75% as metabolites, 10% as unchanged drug), some fecal excretion.

Half life

IV: 3-12 hours (distribution half-life 13-22 min, terminal half-life 3-12 hours).

Absorption

Rapidly absorbed after intravenous administration; bioavailability varies with other routes.

Metabolism

Primarily hepatic, via cytochrome P450 3A4 (CYP3A4), to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to fentanyl or other opioids.
Significant respiratory depression.
Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment.
Paralytic ileus.
Acute pancreatitis.

Drug Interactions

CYP3A4 Inhibitors

Can increase fentanyl plasma concentrations, leading to increased or prolonged opioid effects.

Serotonergic Drugs

May increase the risk of serotonin syndrome.

Benzodiazepines & other CNS Depressants

Increased risk of respiratory depression, profound sedation, coma, and death.

Mixed Agonist/Antagonist Opioid Analgesics

May reduce the analgesic effect and/or precipitate withdrawal symptoms.

Storage

Store at controlled room temperature (20°C to 25°C), away from light and excessive heat. Protect from freezing. Keep in original container.

Overdose

Symptoms include respiratory depression (ranging from bradypnea to apnea), extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and possibly bradycardia and hypotension. Management involves ensuring a patent airway, providing ventilatory support, and administering an opioid antagonist (e.g., naloxone).

Pregnancy & Lactation

Pregnancy Category C. May cause fetal harm. Prolonged use during pregnancy can result in neonatal opioid withdrawal syndrome. Excreted in breast milk; not recommended for use during lactation due to potential for serious adverse reactions in breastfed infants.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 x 2 mL ampoules10 x 2 mL ampoules

Shelf Life

Usually 2-3 years, check specific product labeling.

Availability

Hospitals, Clinics, Pharmacies (with controlled substance license)

Approval Status

FDA Approved

Patent Status

Generic available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials support the efficacy and safety of fentanyl for its approved indications, especially in surgical anesthesia and severe pain management. Ongoing research explores new formulations and applications.

Lab Monitoring

Respiratory rate and depth
Oxygen saturation
Heart rate and blood pressure
Level of consciousness

Doctor Notes

Extreme caution with concomitant use of CNS depressants; consider dose reduction of one or both agents.
Naloxone should be readily available for immediate reversal of respiratory depression.
Monitor for signs of opioid-induced ventilatory impairment (OIVI).
Taper slowly if discontinuing after prolonged use to avoid withdrawal.

Patient Guidelines

This medication will be administered by a healthcare professional.
Report any difficulty breathing, severe dizziness, or confusion immediately.
Do not consume alcohol or other CNS depressants during treatment without consulting your doctor.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.

Missed Dose Advice

This medicine is typically administered in a hospital setting by a healthcare professional. A missed dose is unlikely in this context. If administered for pain management on a schedule, the healthcare provider will determine the appropriate course of action.

Driving Precautions

Fentanyl can cause significant drowsiness, dizziness, and impaired judgment. Do not drive or operate heavy machinery after receiving fentanyl injection.