Medicine Information

Ficef

Name: Ficef
Brand: Ficef
Rating: 4.5 (117 reviews)

Capsule500 mgAntibacterial (Third Generation Cephalosporins)ATC: J01DD08

Generic Name

Cefixime 500 mg capsule

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ficef 500 mg capsule	৳ 15.00	৳ 60.00

Description

Overview of the medicine

Ficef 500 mg capsule contains Cefixime, a third-generation cephalosporin antibiotic. It is effective against a wide range of gram-positive and gram-negative bacteria, used for treating various bacterial infections.

Uses & Indications

Pharyngitis and Tonsillitis

Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis

Uncomplicated Urinary Tract Infections

Otitis Media

Uncomplicated Gonorrhea

Dosage

Adults

Standard adult dose is 500 mg once daily, or as directed by physician for specific indications. Duration of treatment depends on the infection type and severity, typically 7-14 days.

Elderly

No specific dosage adjustment is required for the elderly unless there is significant renal impairment. Monitor renal function.

Renal_impairment

For creatinine clearance 21-60 mL/min, dose reduction may be considered. For creatinine clearance <20 mL/min, a lower dose (e.g., 250 mg once daily) or extended dosing interval is necessary.

How to Take

Ficef 500 mg capsule should be taken orally with water, with or without food. For best absorption and to minimize gastrointestinal upset, it can be taken with food.

Mechanism of Action

Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.

Pharmacokinetics

Onset

Antimicrobial effects typically begin within hours of administration.

Excretion

Excreted primarily via renal and biliary routes, with a significant portion eliminated unchanged in urine.

Half life

Plasma elimination half-life is usually 3-4 hours, potentially longer in renal impairment.

Absorption

Approximately 40-50% orally absorbed. Peak plasma concentrations are achieved in 2-6 hours after administration.

Metabolism

Undergoes limited metabolism; approximately 50% is excreted unchanged in urine.

Side Effects

Contraindications

Hypersensitivity to cefixime or any other cephalosporin antibiotics
History of severe hypersensitivity reaction to penicillin (due to potential cross-reactivity)

Drug Interactions

Carbamazepine

Cefixime may increase carbamazepine plasma concentrations, requiring monitoring of carbamazepine levels.

Warfarin and other oral anticoagulants

Concurrent use may increase prothrombin time (PT) and INR, increasing bleeding risk. Close monitoring of coagulation parameters is recommended.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be symptomatic and supportive. Hemodialysis or peritoneal dialysis does not remove significant quantities of cefixime from the body.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in small amounts in human milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

6 capsules10 capsules12 capsules

Shelf Life

24-36 months from the date of manufacture, specific to lot.

Availability

Pharmacies nationwide

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied in numerous clinical trials for its efficacy and safety in various bacterial infections. Ongoing post-marketing surveillance continues to monitor adverse effects and drug interactions.

Lab Monitoring

Renal function tests (for patients with renal impairment or elderly)
Complete Blood Count (CBC) with differential, especially during prolonged therapy
Liver function tests (LFTs) if treatment is extended

Doctor Notes

Confirm bacterial susceptibility before initiating therapy, if possible.
Adjust dose in patients with significant renal impairment.
Counsel patients on the importance of completing the full course and potential side effects, particularly diarrhea.

Patient Guidelines

Take the full course of medication as prescribed, even if symptoms improve, to prevent antibiotic resistance.
Do not share this medicine with others, even if they have similar symptoms.
Report any severe or persistent side effects to your doctor immediately.
Store at room temperature away from moisture and heat.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for the next dose. Do not double the dose to catch up. Continue with your regular dosing schedule.

Driving Precautions

Cefixime generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid these activities.