Finix
Generic Name
Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
finix 20 mg capsule | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Esomeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. It is used to treat acid-related conditions like GERD, ulcers, and to help heal erosive esophagitis.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg orally once daily for 4-8 weeks. Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. H. pylori eradication: 20 mg twice daily for 10 days with antibiotics.
Elderly
No specific dosage adjustment is generally required, but caution is advised in severe hepatic impairment.
Renal_impairment
No dosage adjustment is necessary for patients with impaired renal function.
How to Take
Take orally, usually 30-60 minutes before a meal. Swallow the capsule whole with water; do not chew, crush, or open the capsule.
Mechanism of Action
Esomeprazole selectively blocks the H+/K+-ATPase (proton pump) in gastric parietal cells, thereby inhibiting both basal and stimulated gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Primarily excreted in urine (approximately 80%) and feces (approximately 20%) as metabolites.
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed. Bioavailability is approximately 64% after a single dose and increases to 89% with repeated daily dosing.
Metabolism
Extensively metabolized in the liver via the cytochrome P450 system (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Known hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
Prolonged elimination of diazepam.
Warfarin
Increased INR and prothrombin time.
Tacrolimus
Increased tacrolimus levels.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel.
Methotrexate
Increased methotrexate levels.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for esomeprazole overdose. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Esomeprazole is excreted in human breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
DGDA Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of GERD, healing of erosive esophagitis, and H. pylori eradication.
Lab Monitoring
- No routine lab monitoring is needed for most patients. Magnesium levels may need monitoring with long-term use (typically >3 months).
Doctor Notes
- Counsel patients on the proper administration of esomeprazole (before meals, swallow whole).
- Educate patients about potential long-term risks with prolonged PPI use and the importance of regular follow-up.
- Consider using the lowest effective dose for the shortest duration necessary to achieve therapeutic goals.
Patient Guidelines
- Take Finix 30-60 minutes before your meal, preferably in the morning.
- Swallow the capsule whole; do not chew, crush, or open it.
- Do not stop taking the medication abruptly without consulting your doctor.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose to make up for a missed one.
Driving Precautions
Generally considered safe for driving. However, if you experience dizziness or visual disturbances, avoid driving or operating machinery until you feel well.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty, or acidic foods that may worsen your symptoms.
- Eat smaller, more frequent meals instead of large ones.
- Avoid lying down immediately after eating; wait at least 2-3 hours.
- Elevate the head of your bed for GERD symptoms.
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Global Brand Names
International brand names for this medicine
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