Medicine Information

Flucopen

Name: Flucopen
Brand: Flucopen
Rating: 4.5 (117 reviews)

Suspension125 mgAntibiotics (Beta-lactamase Resistant Penicillins)ATC: J01CF05

Generic Name

Flucloxacillin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
flucopen 125 mg suspension	৳ 60.23	N/A

Description

Overview of the medicine

Flucopen 125 mg Suspension is an antibiotic used to treat various bacterial infections, primarily those caused by Staphylococcus bacteria. It belongs to the penicillin group of antibiotics and is effective against beta-lactamase producing bacteria.

Uses & Indications

Skin and soft tissue infections (e.g., cellulitis, carbuncles, impetigo)

Bone and joint infections (e.g., osteomyelitis)

Respiratory tract infections (e.g., pneumonia, bronchitis)

Urinary tract infections

Other Staphylococcal infections

Dosage

Adults

Not typically used for adults in suspension form; usually 250-500 mg every 6 hours (oral capsule/tablet).

Elderly

No specific dosage adjustment for elderly unless renal impairment.

Children

1-5 years: 125 mg 4 times daily; 5-10 years: 250 mg 4 times daily. Dosage may vary based on infection severity and body weight.

Renal_impairment

Dosage reduction may be necessary for severe renal impairment (creatinine clearance <10 ml/min).

How to Take

Take orally, preferably on an empty stomach (30-60 minutes before food or 2 hours after food) to maximize absorption. Shake the bottle well before each use. Use the provided measuring spoon/cup for accurate dosing.

Mechanism of Action

Flucloxacillin is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This leads to cell lysis and bacterial death. It is resistant to degradation by beta-lactamase enzymes produced by certain bacteria.

Pharmacokinetics

Onset

Within 1-2 hours

Excretion

Mainly excreted unchanged in the urine via glomerular filtration and tubular secretion.

Half life

Approximately 0.5-1.5 hours

Absorption

Well absorbed from the gastrointestinal tract, though absorption is reduced by food. Peak plasma concentrations achieved within 1-2 hours.

Metabolism

Partially metabolized in the liver, primarily to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to flucloxacillin, other penicillins, or any component of the formulation.
History of flucloxacillin-associated jaundice or hepatic dysfunction.
Co-administration with methotrexate.

Drug Interactions

Warfarin

May alter anticoagulant effect; monitor INR.

Methotrexate

Increased methotrexate toxicity due to reduced renal excretion.

Oral Contraceptives

May reduce efficacy of oral contraceptives (though clinical significance is debated, advise additional contraception).

Storage

Store below 30°C in a dry place, protected from light. Keep out of reach of children. After reconstitution, store in a refrigerator (2-8°C) and discard after recommended period.

Overdose

Symptoms may include nausea, vomiting, and diarrhea. Management is symptomatic and supportive. No specific antidote. Haemodialysis is not effective.

Pregnancy & Lactation

Pregnancy: Category B. Generally considered safe, but use only if clearly needed. Lactation: Excreted in breast milk; use with caution. Monitor infants for diarrhea or candidiasis.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 ml suspension60 ml suspension

Shelf Life

24 months (unopened); typically 7-14 days after reconstitution (check specific product leaflet).

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical data available supporting its efficacy and safety profile against susceptible bacterial infections. Ongoing post-marketing surveillance.

Lab Monitoring

Liver function tests (especially with prolonged use or in patients with pre-existing hepatic disease).
Renal function tests (for patients with renal impairment).
Complete blood count (rarely, with long-term therapy).

Doctor Notes

Advise parents on proper measurement and administration techniques for suspension.
Emphasize completion of the full antibiotic course to prevent resistance.
Monitor for signs of hypersensitivity, especially with the first dose.
Be aware of potential liver toxicity, particularly in prolonged or high-dose therapy.

Patient Guidelines

Complete the full course of treatment as prescribed, even if symptoms improve.
Shake the bottle well before each use.
Take on an empty stomach for best absorption.
Store in a cool, dry place away from direct sunlight.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

Driving Precautions

Generally, flucloxacillin is not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.