Medicine Information

Fostat

Name: Fostat
Brand: Fostat
Rating: 4.5 (117 reviews)

Tablet40 mgProton Pump Inhibitors (PPIs)ATC: A02BC02

Generic Name

Pantoprazole

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
fostat 40 mg tablet	৳ 10.00	N/A

Description

Overview of the medicine

Fostat 40 mg Tablet contains Pantoprazole, a proton pump inhibitor used to reduce acid production in the stomach, treating conditions like GERD and ulcers.

Uses & Indications

Gastroesophageal Reflux Disease (GERD)

Erosive Esophagitis (healing and maintenance)

Zollinger-Ellison Syndrome and other pathological hypersecretory conditions

Prevention of NSAID-induced gastric ulcers

Duodenal and Gastric Ulcers (in combination with antibiotics for H. pylori eradication)

Dosage

Adults

GERD/Erosive Esophagitis: 40 mg once daily for up to 8 weeks. Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted as needed. H. pylori eradication: 40 mg twice daily for 7-14 days with appropriate antibiotics.

Elderly

No specific dosage adjustment usually required, but monitor for adverse effects.

Renal_impairment

No dosage adjustment needed for renal impairment. Limited data in severe impairment.

How to Take

Take Fostat 40 mg Tablet once daily before a meal, preferably in the morning. Swallow the tablet whole; do not chew, crush, or split.

Mechanism of Action

Pantoprazole selectively inhibits the H+/K+-ATPase enzyme (proton pump) in the gastric parietal cells, blocking the final step of acid production.

Pharmacokinetics

Onset

Within 2.5 hours, with full acid suppression achieved after several days of therapy.

Excretion

Mainly renal (approximately 80%) and biliary/fecal (approximately 18%) as metabolites.

Half life

Approximately 1 hour (terminal elimination half-life), but acid suppression lasts much longer due to irreversible binding to the proton pump.

Absorption

Rapidly absorbed after oral administration; bioavailability approximately 77%. Peak plasma concentrations within 2-2.5 hours.

Metabolism

Extensively metabolized in the liver via CYP2C19 and CYP3A4 enzymes, primarily by demethylation followed by sulfation.

Side Effects

Contraindications

Hypersensitivity to Pantoprazole, substituted benzimidazoles, or any component of the formulation
Concomitant use with rilpivirine-containing products due to potential reduction in rilpivirine absorption

Drug Interactions

Warfarin

Possible increased INR and prothrombin time; monitor closely.

Tacrolimus

Increased tacrolimus exposure; monitor tacrolimus concentrations.

Clopidogrel

Reduced antiplatelet effect of clopidogrel; consider alternative antiplatelet therapy.

Methotrexate

Possible increased methotrexate levels, especially with high-dose methotrexate; consider temporary PPI discontinuation.

Drugs dependent on gastric pH for absorption (e.g., ketoconazole, atazanavir, nelfinavir, iron salts)

Decreased absorption of these drugs.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach and sight of children.

Overdose

Limited experience with overdose. No specific antidote. Symptomatic and supportive treatment is recommended. Pantoprazole is not readily dialyzable.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Pantoprazole is excreted in breast milk; use with caution in lactating mothers or consider discontinuing nursing or the drug.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister, 3 blisters per box (30 tablets)

Shelf Life

36 months from the date of manufacture.

Availability

Pharmacies nationwide

Approval Status

Approved by regulatory authorities

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied in numerous clinical trials, demonstrating its efficacy and safety in the treatment of GERD, erosive esophagitis, Zollinger-Ellison Syndrome, and H. pylori eradication.

Lab Monitoring

Magnesium levels (for patients on long-term therapy or concomitant diuretics/digoxin)
Chromogranin A (CgA) levels (may be falsely elevated by PPIs, potentially interfering with neuroendocrine tumor diagnosis)
Liver function tests (periodically, especially with signs of hepatic dysfunction)

Doctor Notes

Prescribe the lowest effective dose for the shortest duration necessary to achieve the desired therapeutic effect.
Monitor patients on long-term therapy for potential adverse effects such as hypomagnesemia and bone fracture risk.
Consider testing for H. pylori infection in patients with recurrent GERD or ulcer symptoms.
Advise patients about potential drug interactions, especially with warfarin and clopidogrel.

Patient Guidelines

Take Fostat 40 mg Tablet exactly as prescribed by your doctor.
Do not stop taking the medicine suddenly without consulting your doctor, even if you feel better.
Inform your doctor about all other medications, herbal supplements, and vitamins you are taking.
Seek medical attention if you experience severe diarrhea, persistent abdominal pain, or any signs of an allergic reaction.

Missed Dose Advice

If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Fostat 40 mg Tablet may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery until you know how the medicine affects you.

Lifestyle Advice

Avoid trigger foods and beverages that worsen acid reflux (e.g., spicy foods, fatty foods, caffeine, alcohol).
Eat smaller, more frequent meals instead of large ones.
Avoid lying down immediately after eating; wait at least 2-3 hours.
Elevate the head of your bed to help reduce nighttime reflux symptoms.