Medicine Information

g-calcium-gluconate

Name: g-calcium-gluconate
Brand: g-calcium-gluconate
Rating: 4.5 (117 reviews)

Injection500 mg/10 mLMineral supplements, ElectrolytesATC: A12AA03

Generic Name

g-calcium-gluconate-500-mg-injection

Manufacturer

Generic Manufacturer

Country

Global

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
g calcium gluconate 500 mg injection	৳ 9.78	N/A

Description

Overview of the medicine

Calcium gluconate injection is used to treat conditions caused by low calcium levels in the blood, such as acute hypocalcemia, magnesium toxicity, and to help stabilize the heart in cases of hyperkalemia.

Uses & Indications

Treatment of acute, symptomatic hypocalcemia

Management of magnesium toxicity

Cardiac stabilization in severe hyperkalemia

Calcium channel blocker overdose (adjunctive therapy)

Dosage

Adults

Typical initial dose: 1-2 g (10-20 mL of 10% solution) IV slow push over 5-10 minutes. May be repeated every 6 hours or as continuous infusion as needed. Max 3g per 6 hours.

Elderly

No specific dosage adjustment, but administer with caution due to potential decreased renal function and comorbidities. Monitor calcium levels closely.

Renal_impairment

Use with caution. Dosage adjustments may be necessary, and close monitoring of serum calcium and renal function is critical.

How to Take

Administer intravenously (IV) as a slow injection or diluted in an infusion. Rapid IV injection can cause serious cardiac adverse effects.

Mechanism of Action

Calcium gluconate provides an immediate source of calcium ions, which are essential for nerve, muscle, and cardiac function, bone formation, and blood coagulation. It acts to replenish extracellular and intracellular calcium stores.

Pharmacokinetics

Onset

Rapid, within minutes of IV administration.

Excretion

Primarily renally excreted (glomerular filtration), with some excretion via feces.

Half life

Plasma half-life is approximately 25-50 minutes, but calcium is rapidly distributed to tissues.

Absorption

Rapidly available after intravenous (IV) administration.

Metabolism

Calcium is not metabolized in the traditional sense; it is incorporated into bone or excreted.

Side Effects

Contraindications

Hypercalcemia
Ventricular fibrillation
Concomitant use with IV Ceftriaxone in neonates (due to risk of precipitation)
Digitalis toxicity

Drug Interactions

Thiazide diuretics

Can decrease calcium excretion and increase the risk of hypercalcemia.

Digitalis (Digoxin)

Increased risk of digitalis toxicity (arrhythmias) if given concomitantly. Administer calcium with extreme caution in digitalized patients.

Phosphates, carbonates, bicarbonates

Incompatible in solution; may cause precipitation.

Storage

Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

Symptoms of overdose are typically signs of hypercalcemia, including nausea, vomiting, constipation, thirst, polyuria, muscle weakness, confusion, and in severe cases, cardiac arrhythmias, coma. Management involves discontinuing calcium, rehydration, and administration of loop diuretics.

Pregnancy & Lactation

Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Calcium is excreted in breast milk; use with caution in breastfeeding mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 mL ampoule

Shelf Life

Typically 2-3 years from manufacturing date when stored correctly.

Availability

Hospitals, Pharmacies

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Calcium gluconate is a long-established essential medicine, and extensive clinical trials for its primary indications have been conducted over decades. Recent trials generally focus on specific populations or novel administration methods.

Lab Monitoring

Serum calcium levels (before, during, and after treatment)
ECG monitoring (especially with rapid administration or in digitalized patients)
Renal function (for prolonged therapy or in patients with kidney impairment)
Serum magnesium and phosphate levels

Doctor Notes

Always administer slowly to minimize the risk of cardiac arrhythmias and hypotension.
Close monitoring of ECG and serum calcium levels is crucial, especially in patients receiving digitalis or with renal impairment.
Ensure patency of IV access to prevent extravasation and local tissue damage.

Patient Guidelines

This medication is administered by a healthcare professional in a medical setting.
Inform your doctor or nurse if you experience any pain, swelling, or redness at the injection site.
Report any unusual symptoms such as nausea, dizziness, or changes in heart rate immediately.

Missed Dose Advice

Calcium gluconate injection is typically administered in a hospital or clinical setting by a healthcare professional, so missed doses are unlikely. If a dose is missed in an emergency, it will be administered as soon as feasible.

Driving Precautions

Since this injection is typically given in acute or emergency situations and may cause dizziness, patients should avoid driving or operating heavy machinery until they feel well and alert.

Lifestyle Advice

No specific lifestyle advice directly related to acute intravenous calcium gluconate administration.

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