Medicine Information

Hybrox

Name: Hybrox
Brand: Hybrox
Rating: 4.5 (117 reviews)

Capsule75 mgAnti-epileptic, Neuropathic pain management, AnxiolyticATC: N03AX16

Generic Name

Pregabalin

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
hybrox 75 mg capsule	৳ 5.00	N/A

Description

Overview of the medicine

Hybrox 75 mg Capsule contains Pregabalin, which is primarily used to treat neuropathic pain, fibromyalgia, and as an adjunct therapy for partial onset seizures in adults. It works by calming damaged or overactive nerves in the body.

Uses & Indications

Neuropathic pain (e.g., diabetic peripheral neuropathy, postherpetic neuralgia)

Fibromyalgia

Adjunctive therapy for partial onset seizures in adults

Generalized Anxiety Disorder (GAD)

Dosage

Adults

Starting dose usually 75 mg twice daily, may be increased up to 300 mg twice daily depending on response and tolerability. For some indications, up to 600 mg/day in divided doses.

Elderly

No specific dose adjustment needed based on age alone, but renal function should be assessed.

Renal_impairment

Dosage must be adjusted based on creatinine clearance. Lower doses are required for patients with impaired renal function.

How to Take

Take orally with or without food. Swallow the capsule whole with water. Do not crush, chew, or open the capsule.

Mechanism of Action

Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of several neurotransmitters like glutamate, norepinephrine, and substance P. This action is believed to modulate the overactivity of neurons responsible for pain signaling and seizure generation.

Pharmacokinetics

Onset

Within 1 week for neuropathic pain; varies for other indications.

Excretion

Primarily excreted unchanged in the urine (approximately 98%).

Half life

Approximately 6.3 hours.

Absorption

Rapidly absorbed after oral administration, reaching peak plasma concentrations within 1.5 hours.

Metabolism

Negligible hepatic metabolism; does not induce or inhibit liver enzymes.

Side Effects

Contraindications

Hypersensitivity to Pregabalin or any component of the formulation.
Severe renal impairment without dose adjustment.

Drug Interactions

CNS Depressants (e.g., Opioids, Benzodiazepines, Alcohol)

May enhance the central nervous system (CNS) depressant effects of Pregabalin, leading to increased sedation, dizziness, and respiratory depression.

Thiazolidinedione Antidiabetic Agents (e.g., Rosiglitazone, Pioglitazone)

May increase the risk of weight gain and peripheral edema when co-administered with Pregabalin.

Storage

Store at room temperature (below 30°C) in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Management is primarily supportive; gastric lavage may be considered soon after ingestion. Hemodialysis can remove Pregabalin from the plasma.

Pregnancy & Lactation

Pregnancy Category C. Should only be used if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per box30 capsules per box

Shelf Life

36 months from manufacturing date

Availability

Available in pharmacies nationwide

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Generic available

Clinical Trials

Extensive clinical trials have established Pregabalin's efficacy and safety for its approved indications, including studies on neuropathic pain, fibromyalgia, and epilepsy. Ongoing research continues to explore its potential in other therapeutic areas.

Lab Monitoring

No routine laboratory monitoring is specifically required for Pregabalin, but renal function should be monitored in patients with pre-existing renal impairment.

Doctor Notes

Counsel patients on the risk of CNS depression when co-administered with other CNS depressants, including alcohol.
Advise patients not to abruptly discontinue treatment to avoid potential withdrawal symptoms.
Monitor for signs of angioedema and hypersensitivity reactions, especially after initiation or dose escalation.

Patient Guidelines

Do not stop taking this medicine suddenly without consulting your doctor, as it may lead to withdrawal symptoms.
Report any unusual mood changes, thoughts of self-harm, or worsening depression to your doctor immediately.
Be cautious when engaging in activities requiring mental alertness, such as driving or operating machinery, until you know how this medicine affects you.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Hybrox may cause dizziness, somnolence, and blurred vision, which can impair your ability to drive or operate machinery. Avoid these activities until you are certain you can perform them safely.

Lifestyle Advice

Avoid alcohol consumption while taking Hybrox, as it can increase drowsiness and dizziness.
Maintain regular exercise and a balanced diet to manage potential weight gain.