Medicine Information

Intasone

Name: Intasone
Brand: Intasone
Rating: 4.5 (117 reviews)

Cream0.1% w/wTopical CorticosteroidsATC: D07AC13

Generic Name

Mometasone Furoate

Manufacturer

Intas Pharmaceuticals Ltd.

Country

India

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
intasone 1 cream	৳ 30.00	N/A

Description

Overview of the medicine

Intasone-1-cream contains Mometasone Furoate, a potent corticosteroid used to treat various inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Uses & Indications

Eczema

Psoriasis

Atopic Dermatitis

Contact Dermatitis

Seborrheic Dermatitis

Pruritus

Dosage

Adults

Apply a thin film to the affected skin areas once daily.

Elderly

No specific dosage adjustment is required, but use with caution due to potentially thinner skin and increased absorption.

Renal_impairment

Not applicable for topical use due to minimal systemic absorption.

How to Take

For external use only. Apply a thin layer to the affected skin area. Gently rub in. Do not use on the face, groin, or underarms unless directed by a doctor. Do not cover the treated area with occlusive dressings unless specifically instructed by a physician.

Mechanism of Action

Mometasone Furoate acts as an anti-inflammatory, antipruritic, and vasoconstrictive agent. It induces phospholipase A2 inhibitory proteins, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Pharmacokinetics

Onset

Onset of action typically occurs within hours to days after initial application, with peak effects within 1-2 weeks.

Excretion

Metabolites are excreted primarily via urine and feces.

Half life

Not precisely determined for topical application due to minimal systemic absorption; systemic half-life of absorbed Mometasone Furoate is approximately 5-6 hours.

Absorption

Minimal systemic absorption (approximately 0.4%) through intact skin. Absorption may increase with skin damage, inflammation, or occlusive dressings.

Metabolism

Any systemically absorbed drug is primarily metabolized in the liver to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to Mometasone Furoate or any component of the cream
Untreated bacterial, fungal, viral (e.g., herpes simplex, varicella), or parasitic skin infections
Rosacea
Perioral dermatitis
Acne
Perianal and genital pruritus

Drug Interactions

Immunosuppressants

Theoretically, if significant systemic absorption occurs, may enhance immunosuppressive effects, but this is rare with topical application.

Storage

Store below 30°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.

Overdose

Excessive or prolonged use of topical corticosteroids can suppress pituitary-adrenal function, potentially leading to secondary adrenal insufficiency and manifestations of Cushing's syndrome. Symptomatic treatment and gradual withdrawal of the drug are recommended.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable amounts in breast milk. Use with caution in nursing mothers and only if clearly needed.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 g tube15 g tube20 g tube

Shelf Life

24 to 36 months (typically 2-3 years)

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies

Patent Status

Off-patent

Clinical Trials

Mometasone Furoate has been extensively studied in clinical trials, demonstrating its efficacy and safety for various corticosteroid-responsive dermatoses. Studies have shown significant improvement in symptoms like erythema, induration, and pruritus compared to placebo.

Lab Monitoring

Not routinely required for topical use. Adrenal function tests (e.g., plasma cortisol levels) may be considered in cases of extensive prolonged use, especially in children, or if systemic absorption is suspected.

Doctor Notes

Educate patients on proper application technique and duration of use to minimize local and systemic side effects.
Monitor patients for signs of skin atrophy, telangiectasia, or other corticosteroid-induced dermatological changes.
Advise against prolonged use on the face or in intertriginous areas unless specifically indicated.

Patient Guidelines

Use this medicine exactly as prescribed by your doctor.
Wash your hands before and after applying the cream.
Apply a thin layer to the affected area and rub it in gently. Do not use more than directed.
Avoid contact with eyes, mouth, and other mucous membranes.
Do not apply to broken, infected, or injured skin unless advised by your doctor.
Do not cover the treated area with bandages or other dressings unless directed by your doctor.

Missed Dose Advice

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.