Medicine Information

Iretavir

Name: Iretavir
Brand: Iretavir
Rating: 4.5 (117 reviews)

Tablet1 mgAntiviral Agent, ImmunomodulatorATC: J05AX19

Generic Name

Iretavir 1 mg Tablet

Manufacturer

MediCare Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
iretavir 1 mg tablet	৳ 90.00	৳ 900.00

Description

Overview of the medicine

Iretavir 1 mg Tablet is an antiviral and immunomodulatory medicine used in the management of specific viral infections. It works by inhibiting viral replication and modulating the host immune response.

Uses & Indications

Treatment of chronic viral hepatitis B (CVHB) in adults.

Management of certain immune-compromised viral infections.

Adjunctive therapy in severe influenza cases.

Dosage

Adults

1 mg once daily, with or without food. Duration of treatment depends on the specific viral infection and patient response.

Elderly

No specific dose adjustment required based on age, but renal function should be monitored.

Renal_impairment

Dose adjustment may be necessary for patients with creatinine clearance <30 mL/min; consult physician.

How to Take

Take orally, with or without food. Swallow the tablet whole with a glass of water; do not crush, chew, or break.

Mechanism of Action

Iretavir selectively targets viral enzymes essential for replication, thereby inhibiting the virus's ability to multiply. It also modulates cytokine pathways, enhancing the host's innate and adaptive immune responses to viral pathogens.

Pharmacokinetics

Onset

Within 24-48 hours of initial dose.

Excretion

Mainly excreted renally (60-70%) and partially through feces (20-30%).

Half life

Approximately 8-12 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours.

Metabolism

Primarily metabolized in the liver via CYP3A4 pathway.

Side Effects

Contraindications

Hypersensitivity to Iretavir or any component of the tablet.
Severe hepatic impairment.
Children under 2 years of age.

Drug Interactions

CYP3A4 inducers (e.g., rifampicin)

May decrease Iretavir plasma concentrations, potentially reducing efficacy.

CYP3A4 inhibitors (e.g., ketoconazole)

May increase Iretavir plasma concentrations, requiring dose adjustment.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, symptomatic and supportive measures should be taken. Hemodialysis is not likely to be effective in removing Iretavir.

Pregnancy & Lactation

Use in pregnancy only if potential benefit outweighs the potential risk to the fetus. It is unknown whether Iretavir is excreted in human milk; caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10's pack)30 tablets (3x10's pack)

Shelf Life

24 months from the date of manufacture

Availability

Available in pharmacies and hospitals nationwide

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Under patent

Clinical Trials

Iretavir has undergone extensive Phase I, II, and III clinical trials demonstrating its efficacy and safety in various viral indications.

Lab Monitoring

Liver function tests (ALT, AST, bilirubin) at baseline and periodically during treatment.
Renal function tests (creatinine, eGFR) at baseline and periodically.
Complete blood count (CBC) periodically.

Doctor Notes

Emphasize patient compliance for optimal therapeutic outcomes.
Educate patients on potential drug interactions, especially with CYP3A4 modulators.
Regular follow-up for viral load and clinical assessment is crucial.

Patient Guidelines

Take Iretavir exactly as prescribed by your doctor.
Do not stop taking the medicine without consulting your doctor, even if you feel better.
Inform your doctor about all other medicines, supplements, or herbal products you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.