Medicine Information

Irita

Name: Irita
Brand: Irita
Rating: 4.5 (117 reviews)

Injection20 mgProton Pump Inhibitor (PPI)ATC: A02BC04

Generic Name

Rabeprazole Sodium

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
irita 20 mg injection	৳ 1,600.00	N/A

Description

Overview of the medicine

Irita 20 mg Injection contains Rabeprazole Sodium, a proton pump inhibitor used to reduce the amount of acid produced in the stomach. It is typically used for conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome, especially when oral administration is not feasible.

Uses & Indications

Gastroesophageal Reflux Disease (GERD) with or without esophageal erosion.

Healing of duodenal ulcers.

Treatment of gastric ulcers.

Zollinger-Ellison Syndrome and other pathological hypersecretory conditions.

For patients unable to take oral rabeprazole.

Dosage

Adults

The usual recommended dose is 20 mg once daily, administered by intravenous infusion over 15 minutes.

Elderly

No dosage adjustment is required for elderly patients.

Renal_impairment

No dosage adjustment is necessary for patients with mild to moderate renal impairment. For severe renal impairment, use with caution.

How to Take

Irita 20 mg Injection is for intravenous use only. It should be reconstituted with the provided solvent and administered as a slow infusion over 15 minutes. Do not administer as a bolus injection.

Mechanism of Action

Rabeprazole irreversibly inhibits the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cells. This inhibition leads to a dose-dependent blockade of the final step of acid secretion, thereby reducing both basal and stimulated acid output.

Pharmacokinetics

Onset

Acid secretion inhibition begins within 1 hour of administration.

Excretion

Approximately 90% of a dose is excreted in the urine as metabolites, with the remainder recovered in the feces.

Half life

Approximately 1 to 2 hours in healthy adults, but the duration of pharmacodynamic effect is much longer.

Absorption

Administered intravenously, rabeprazole bypasses first-pass metabolism, ensuring complete bioavailability. Peak plasma concentrations are achieved rapidly.

Metabolism

Primarily metabolized in the liver by the cytochrome P450 (CYP450) system, mainly CYP2C19 and CYP3A4, to inactive metabolites.

Side Effects

Contraindications

Known hypersensitivity to rabeprazole, other substituted benzimidazoles, or any component of the formulation.
Co-administration with atazanavir or nelfinavir due to significant reduction in antiretroviral plasma levels.

Drug Interactions

Digoxin

Increased digoxin absorption due to altered gastric pH; monitor digoxin levels.

Warfarin

Increased INR/prothrombin time; monitor closely.

Clopidogrel

Potential reduction in clopidogrel's antiplatelet effect; clinical significance debated.

Methotrexate

Increased methotrexate levels, particularly with high doses; consider temporary rabeprazole withdrawal.

Drugs dependent on gastric pH for absorption (e.g., ketoconazole, iron salts)

Reduced absorption.

Storage

Store below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

There is no specific antidote for rabeprazole overdose. In case of overdose, treatment should be symptomatic and supportive. Rabeprazole is not readily dialyzable.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is unknown whether rabeprazole is excreted in human milk; use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 vial per pack

Shelf Life

36 months from manufacturing date.

Availability

Hospitals, Pharmacies

Approval Status

Approved (DGDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of rabeprazole for various acid-related disorders. Ongoing research continues to explore its role in different patient populations and long-term outcomes.

Lab Monitoring

Monitor liver function tests periodically, especially in patients with severe hepatic impairment.
Magnesium levels should be monitored in patients expected to be on long-term treatment (e.g., >3 months) or taking rabeprazole with other drugs that may cause hypomagnesemia.

Doctor Notes

Consider IV formulation for acute conditions or when oral intake is compromised (e.g., severe GERD, bleeding ulcers).
Rule out malignancy before initiating therapy for gastric ulcers.
Be aware of potential drug interactions, especially with antiplatelet agents and HIV antivirals.

Patient Guidelines

Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Report any unusual or severe side effects to your doctor immediately.
Do not stop taking the medication without consulting your doctor.

Missed Dose Advice

If a dose is missed, administer it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Rabeprazole may cause dizziness, somnolence, or visual disturbances in some patients. Patients experiencing these effects should avoid driving or operating machinery.

Lifestyle Advice

Avoid foods and drinks that may worsen your acid reflux symptoms, such as spicy foods, fatty foods, caffeine, and alcohol.
Maintain a healthy weight and avoid lying down immediately after meals to reduce symptoms.