Medicine Information

Ketofast

Name: Ketofast
Brand: Ketofast
Rating: 4.5 (117 reviews)

Tablet10 mgNon-steroidal Anti-inflammatory Drugs (NSAIDs)ATC: M01AB15

Generic Name

Ketorolac Tromethamine

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ketofast 10 mg tablet	৳ 12.04	৳ 120.40

Description

Overview of the medicine

Ketofast 10 mg Tablet contains Ketorolac Tromethamine, which is a non-steroidal anti-inflammatory drug (NSAID). It is primarily used for the short-term management of moderately severe acute pain that requires analgesia at the opioid level, typically after surgical procedures. It is not indicated for chronic pain management.

Uses & Indications

Short-term management of moderately severe acute pain requiring analgesia at the opioid level.

Post-operative pain.

Acute musculoskeletal pain.

Dosage

Adults

The recommended oral dose is 10 mg every 4 to 6 hours as needed, not to exceed 40 mg in 24 hours. Treatment should not exceed 5 days.

Elderly

Lower doses (e.g., 10 mg every 6-8 hours) may be required due to increased risk of adverse effects, especially renal impairment. Max 40 mg/day.

Renal_impairment

Contraindicated in patients with advanced renal impairment. For mild to moderate impairment, dose reduction is necessary, and caution is advised. Consult physician for specific guidance.

How to Take

Take the tablet orally, with food or milk to minimize gastrointestinal upset. Do not crush or chew the tablet.

Mechanism of Action

Ketorolac inhibits prostaglandin synthesis by non-selectively blocking the cyclooxygenase (COX-1 and COX-2) enzymes. This action leads to reduced inflammation, pain, and fever.

Pharmacokinetics

Onset

Analgesic effect begins within 30-60 minutes.

Excretion

Primarily excreted renally (approximately 91% as unchanged drug and metabolites); a small amount (6%) is excreted in feces.

Half life

Approximately 4-6 hours (ranges from 2.5 to 9 hours depending on age and renal function).

Absorption

Rapidly and completely absorbed orally. Peak plasma concentrations are reached within 30-60 minutes.

Metabolism

Extensively metabolized in the liver, primarily via hydroxylation and conjugation. Main metabolite is p-hydroxyketorolac.

Side Effects

Contraindications

Known hypersensitivity to Ketorolac, aspirin, or other NSAIDs.
Active gastrointestinal bleeding, ulceration, or perforation.
Advanced renal impairment.
History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Concomitant use with other NSAIDs, aspirin, anticoagulants, probenecid, or pentoxifylline.

Drug Interactions

Lithium

Increased plasma lithium levels, leading to toxicity.

Probenecid

Reduced clearance of Ketorolac, increasing its levels and risk of toxicity.

SSRIs/SNRIs

Increased risk of gastrointestinal bleeding.

Methotrexate

Increased methotrexate toxicity.

Pentoxifylline

Increased risk of bleeding.

ACE Inhibitors/ARBs

Reduced antihypertensive effect and increased risk of renal impairment.

Aspirin/Other NSAIDs

Increased risk of gastrointestinal adverse effects.

Diuretics (e.g., Furosemide)

Reduced diuretic and antihypertensive effects. Increased risk of renal impairment.

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Storage

Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. Rare symptoms include hypertension, acute renal failure, respiratory depression, and coma. Management involves symptomatic and supportive treatment. There is no specific antidote. Gastric decontamination (e.g., activated charcoal) may be considered within an hour of ingestion.

Pregnancy & Lactation

Pregnancy Category C (first and second trimesters), Category D (third trimester and peripartum period). Ketorolac should be avoided during late pregnancy due to potential adverse effects on the fetus and inhibition of uterine contractions. Not recommended during breastfeeding as Ketorolac is excreted in human milk and may cause adverse effects in a nursing infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10's)

Shelf Life

24 to 36 months from manufacturing date.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic available

Clinical Trials

Ketorolac has been extensively studied in clinical trials for its efficacy in acute pain management, particularly post-operative pain. Studies have demonstrated its non-opioid analgesic potency.

Lab Monitoring

Renal function (serum creatinine, BUN) before and during treatment, especially in elderly or patients with pre-existing renal impairment.
Liver function tests (ALT, AST) periodically, particularly with long-term use.
Complete blood count (CBC) if used for an extended period, to monitor for anemia or bleeding.

Doctor Notes

Emphasize short-term use only (max 5 days) to minimize serious risks.
Assess renal and cardiovascular risk factors before prescribing, especially in elderly patients.
Avoid concomitant use with other NSAIDs, anticoagulants, and nephrotoxic drugs.
Educate patients on symptoms of GI bleeding and cardiovascular events.

Patient Guidelines

Do not take for more than 5 days without consulting a doctor.
Take with food or milk to reduce stomach upset.
Inform your doctor about all other medications, supplements, and herbal products you are taking.
Report any signs of unusual bleeding, severe stomach pain, black stools, or allergic reactions immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

This medication may cause dizziness, drowsiness, or visual disturbances. If you experience these effects, avoid driving or operating machinery.

Lifestyle Advice

Avoid alcohol consumption while taking this medication as it may increase the risk of stomach bleeding.
Maintain adequate hydration, especially if you have renal issues.
Do not exceed the recommended dose or duration of treatment.