Medicine Information

Ketomar

Name: Ketomar
Brand: Ketomar
Rating: 4.5 (117 reviews)

Eye Drop0.025% w/v (0.25 mg/mL)Ophthalmic NSAIDsATC: S01BC05

Generic Name

Ketorolac Tromethamine Ophthalmic Solution

Manufacturer

Fictional Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ketomar 0025 eye drop	৳ 100.00	N/A

Description

Overview of the medicine

Ketorolac Tromethamine is a non-steroidal anti-inflammatory drug (NSAID) used as an ophthalmic solution to reduce inflammation and pain in the eyes, particularly after cataract surgery and for seasonal allergic conjunctivitis. This 0.025% strength is a specific formulation for ophthalmic use.

Uses & Indications

For the treatment of post-operative inflammation following cataract extraction.

For the temporary relief of ocular itching due to seasonal allergic conjunctivitis.

For the treatment of pain and photophobia following refractive surgery.

Dosage

Adults

For post-operative inflammation: One drop into the affected eye(s) four times daily, starting 24 hours after surgery and continuing for up to two weeks. For seasonal allergic conjunctivitis: One drop into the affected eye(s) four times daily for temporary relief.

Elderly

No specific dosage adjustment is generally required for elderly patients.

Renal_impairment

No specific dosage adjustment required for ophthalmic use due to minimal systemic absorption.

How to Take

Wash hands thoroughly before use. Tilt head back, pull down the lower eyelid to form a pocket. Squeeze one drop into the pocket without touching the eye or eyelid with the dropper tip. Close the eye gently for a moment. If using other eye drops, wait at least 5 minutes between applications.

Mechanism of Action

Ketorolac acts by inhibiting prostaglandin synthesis through the inhibition of cyclooxygenase (COX-1 and COX-2) enzymes. Prostaglandins are mediators of inflammation and pain. By reducing prostaglandin levels, ketorolac effectively diminishes ocular inflammation and pain.

Pharmacokinetics

Onset

Ocular analgesic effect typically observed within 1 hour.

Excretion

Excreted primarily in urine (for systemically absorbed drug) and feces.

Half life

Systemic half-life is approximately 5-7 hours, but local ocular effects are more clinically relevant.

Absorption

Following topical ocular administration, systemic absorption is minimal. Peak plasma concentrations are very low, typically below detectable limits, indicating primarily local action.

Metabolism

Systemically absorbed ketorolac undergoes hepatic metabolism.

Side Effects

Contraindications

Hypersensitivity to ketorolac tromethamine or any component of the formulation, or to other NSAIDs.
Patients with a history of bleeding tendencies or coagulation disorders.
Concurrent use with other topical NSAIDs.

Drug Interactions

Systemic NSAIDs

Although systemic absorption is minimal, caution is advised if used concurrently with systemic NSAIDs or anticoagulants, especially in patients prone to bleeding.

Other Ophthalmic Medications

If more than one topical ophthalmic medication is being used, they should be administered at least 5 minutes apart.

Storage

Store below 30°C in a dry place, protected from light. Do not freeze. Keep out of reach of children.

Overdose

Ophthalmic overdose is unlikely to lead to systemic toxicity due to minimal absorption. If excessive drops are accidentally applied, the eye may be flushed with lukewarm water.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether ophthalmic ketorolac is excreted in human milk; caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 mL bottle10 mL bottle

Shelf Life

2 years (unopened), 28 days after opening.

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Generic

Clinical Trials

Clinical trials have demonstrated the efficacy and safety of Ketorolac Tromethamine ophthalmic solution in reducing ocular inflammation and pain following various ophthalmic surgeries and in managing seasonal allergic conjunctivitis.

Lab Monitoring

No specific laboratory monitoring is typically required for ophthalmic ketorolac due to minimal systemic absorption.

Doctor Notes

Emphasize short-term use, especially in post-operative settings.
Counsel patients on proper administration technique to prevent contamination and maximize efficacy.
Be cautious in patients with known bleeding disorders or those on anticoagulants, though systemic absorption is minimal.

Patient Guidelines

Do not touch the dropper tip to any surface (including the eye) to avoid contamination.
Remove contact lenses before applying the eye drop and wait at least 15 minutes before reinserting them.
If you experience persistent eye irritation, pain, or vision changes, discontinue use and consult your doctor.

Missed Dose Advice

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.