Medicine Information

Labeta

Name: Labeta
Brand: Labeta
Rating: 4.5 (117 reviews)

Tablet200 mgBeta-adrenoceptor blocking drug (beta-blocker) with alpha1-blocking activityATC: C07AG01

Generic Name

Labetalol 200 mg Tablet

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
labeta 200 mg tablet	৳ 9.00	৳ 90.00

Description

Overview of the medicine

Labetalol is a combined alpha- and beta-adrenoceptor blocker used to treat hypertension and angina. It effectively lowers blood pressure by reducing peripheral vascular resistance and heart rate.

Uses & Indications

Management of hypertension (mild to severe)

Hypertensive emergencies

Angina pectoris (when beta-blockers are indicated)

Controlled hypotension during anesthesia

Dosage

Adults

Initial dose 100 mg twice daily; usual maintenance 200-400 mg twice daily. Max 2400 mg/day.

Elderly

Start with lower doses (e.g., 50 mg twice daily) and titrate slowly due to potential for increased sensitivity and co-morbidities.

Renal_impairment

No significant dose adjustment needed for renal impairment, but caution advised.

How to Take

Oral tablets should be taken with food, preferably after a meal, to enhance bioavailability and reduce orthostatic effects. Do not crush or chew.

Mechanism of Action

Labetalol is a non-selective beta-adrenergic blocker and a selective alpha1-adrenergic blocker. It competitively blocks beta1 and beta2 receptors and also blocks alpha1 receptors, leading to vasodilation and reduced heart rate and contractility, thus lowering blood pressure.

Pharmacokinetics

Onset

Oral: 20 minutes - 2 hours; IV: 2-5 minutes

Excretion

Primarily renal (approx. 55-60%) as metabolites and unchanged drug; some via feces.

Half life

Approximately 6-8 hours

Absorption

Well absorbed from the GI tract (approx. 90%), but undergoes extensive first-pass metabolism, resulting in approximately 25% oral bioavailability.

Metabolism

Extensively metabolized in the liver, primarily via conjugation and glucuronidation.

Side Effects

Contraindications

Bronchial asthma or history of obstructive airway disease
Heart failure (decompensated)
Second or third-degree AV block
Cardiogenic shock
Severe bradycardia
Hypotension

Drug Interactions

Cimetidine

Increases Labetalol bioavailability.

General anesthetics

May potentiate hypotensive effects.

Tricyclic antidepressants

May increase risk of tremor.

Non-steroidal anti-inflammatory drugs (NSAIDs)

May reduce antihypertensive effect.

Calcium channel blockers (e.g., verapamil, diltiazem)

Increased risk of bradycardia and heart block.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms include severe hypotension, bradycardia, heart failure, bronchospasm. Management involves supportive measures, IV fluids, atropine for bradycardia, glucagon, and potentially vasopressors.

Pregnancy & Lactation

Pregnancy category C. Use during pregnancy only if potential benefit justifies potential risk to the fetus. Excreted in breast milk; caution advised during lactation. Consult doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 x 10 tablets (blister)

Shelf Life

Typically 2-3 years from manufacturing date

Availability

Pharmacies, hospitals

Approval Status

Approved by regulatory authorities (e.g., FDA, DGDA)

Patent Status

Generic available (patent expired)

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established Labetalol's efficacy and safety in various hypertensive conditions, including pre-eclampsia and hypertensive emergencies.

Lab Monitoring

Blood pressure monitoring
Heart rate monitoring
Liver function tests (periodically)

Doctor Notes

Labetalol is effective in hypertensive emergencies, especially where a rapid reduction in blood pressure is required without reflex tachycardia.
Caution in patients with chronic obstructive pulmonary disease (COPD) due to beta-2 blocking activity.
Monitor blood pressure and heart rate closely during initiation and dose adjustments.

Patient Guidelines

Take with food for best absorption.
Do not stop taking this medicine abruptly without consulting your doctor.
Report any dizziness, slow heart rate, or difficulty breathing to your doctor.
Avoid sudden changes in position to minimize orthostatic hypotension.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

May cause dizziness or fatigue, especially at the start of treatment or when dosage is adjusted. Avoid driving or operating heavy machinery until you know how this medicine affects you.

Lifestyle Advice

Maintain a healthy diet low in sodium.
Engage in regular physical activity.
Avoid smoking and excessive alcohol consumption.
Manage stress effectively.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Labe (ACI Pharma)Labesil (Incepta Pharma)

Global Brand Names

International brand names for this medicine