Medicine Information

Lefabac

Name: Lefabac
Brand: Lefabac
Rating: 4.5 (117 reviews)

Tablet600 mgAntibiotics (Fluoroquinolone)ATC: J01MA12

Generic Name

Levofloxacin 600 mg tablet

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
lefabac 600 mg tablet	৳ 850.00	৳ 8,500.00

Description

Overview of the medicine

Lefabac 600 mg Tablet is an antibiotic belonging to the fluoroquinolone group, containing Levofloxacin. It is used to treat a wide range of bacterial infections affecting the lungs, skin, urinary tract, and other areas of the body.

Uses & Indications

Community-acquired pneumonia

Acute bacterial sinusitis

Acute exacerbation of chronic bronchitis

Complicated skin and soft tissue infections

Complicated and uncomplicated urinary tract infections

Pyelonephritis

Dosage

Adults

The usual dose is 600 mg once daily, administered orally. Duration of treatment depends on the type and severity of infection, typically 7 to 14 days.

Elderly

No specific dose adjustment required based solely on age, but renal function should be assessed, and dose adjusted if needed.

Renal_impairment

Dose reduction is necessary for patients with creatinine clearance less than 50 mL/min. Consult a physician for specific dosage adjustments.

How to Take

Lefabac 600 mg Tablet can be taken with or without food. Swallow the tablet whole with a sufficient amount of water. Do not crush or chew the tablet.

Mechanism of Action

Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV enzymes, which are essential for bacterial DNA replication, transcription, repair, and recombination. By inhibiting these enzymes, it leads to bacterial cell death.

Pharmacokinetics

Onset

Onset of action varies depending on the type and severity of infection, typically within a few hours of the first dose.

Excretion

Primarily excreted unchanged in the urine, mainly by glomerular filtration and tubular secretion.

Half life

The elimination half-life is approximately 6 to 8 hours.

Absorption

Rapid and almost complete oral absorption. Bioavailability is approximately 99%. Peak plasma concentrations are reached within 1 to 2 hours after oral administration.

Metabolism

Minimally metabolized in the liver; less than 5% of the dose is metabolized to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to levofloxacin, other quinolones, or any excipients of the product.
Patients with a history of tendon disorders related to fluoroquinolone administration.
Epilepsy.
Children or adolescents below 18 years of age.
Pregnancy and breastfeeding.

Drug Interactions

Warfarin

May enhance the anticoagulant effects of warfarin. Close monitoring of INR (International Normalized Ratio) is recommended.

Corticosteroids

Concomitant use with corticosteroids may increase the risk of tendon rupture.

Antidiabetic Agents

May cause dysglycemia (hypoglycemia or hyperglycemia), especially in diabetic patients. Monitor blood glucose levels.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

May increase the risk of CNS stimulation and convulsive seizures when co-administered with fluoroquinolones.

Antacids (magnesium/aluminum), Sucralfate, Metal Cations (iron, zinc)

Reduce oral absorption of levofloxacin. Administer levofloxacin at least 2 hours before or 2 hours after these agents.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

In the event of an overdose, gastric lavage may be considered. Symptomatic and supportive treatment should be initiated. Hemodialysis or peritoneal dialysis is not effective in removing levofloxacin from the body.

Pregnancy & Lactation

Levofloxacin is classified as Pregnancy Category C. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Levofloxacin is excreted into breast milk; therefore, breastfeeding is generally not recommended during treatment.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 7 tablets

Shelf Life

36 months

Availability

Available in pharmacies and hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Levofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety across various bacterial infections. Post-marketing surveillance continues to monitor for rare adverse events.

Lab Monitoring

Renal function tests (creatinine clearance) in elderly or renally impaired patients.
Blood glucose levels in diabetic patients.
INR (International Normalized Ratio) in patients receiving warfarin.

Doctor Notes

Counsel patients on the Black Box Warning for fluoroquinolones, emphasizing the risk of tendinitis, tendon rupture, peripheral neuropathy, and CNS effects.
Ensure proper hydration, especially in patients at risk of crystalluria.
Adjust dose for renal impairment and monitor blood glucose in diabetic patients.
Avoid co-administration with multivalent cations; separate dosing by at least 2 hours.

Patient Guidelines

Complete the full prescribed course of medicine, even if you start feeling better, to prevent the return of infection and development of antibiotic resistance.
Stay well-hydrated by drinking plenty of fluids.
Avoid excessive sun exposure and use sunscreen, as levofloxacin can increase photosensitivity.
Report any new or worsening symptoms, especially tendon pain, numbness, tingling, or changes in mood, immediately to your doctor.
Do not take antacids, sucralfate, or mineral supplements containing iron or zinc within 2 hours of taking Lefabac.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Lefabac may cause dizziness, lightheadedness, or visual disturbances. Patients should be cautioned about driving or operating machinery until they know how the medicine affects them.