Medicine Information

Liana

Name: Liana
Brand: Liana
Rating: 4.5 (117 reviews)

Tablet3 mgHormonal Contraceptive; Progestin; Treatment for EndometriosisATC: G03DC08

Generic Name

Dienogest 3 mg Tablet

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
liana 3 mg tablet	৳ 1,500.00	N/A

Description

Overview of the medicine

Liana 3 mg tablet contains Dienogest, a progestin, primarily used for the treatment of endometriosis and as an oral contraceptive. It helps in reducing pain associated with endometriosis and regulates the menstrual cycle.

Uses & Indications

Treatment of endometriosis

Oral contraception (in specific formulations)

Management of uterine bleeding disorders

Dosage

Adults

One 3 mg tablet daily without interruption, preferably at the same time each day, regardless of food intake.

Elderly

Not indicated for postmenopausal women. No specific dosage adjustment for elderly women prior to menopause is required, but clinical data are limited.

Renal_impairment

No specific dosage adjustment is recommended, but caution is advised in severe renal impairment.

How to Take

Take one tablet daily, preferably at the same time each day, with or without food. Swallow the tablet whole with a sufficient amount of liquid. Do not chew or crush.

Mechanism of Action

Dienogest is a 19-norprogestin derivative with high progestogenic activity and moderate antiandrogenic activity. It reduces the endogenous production of estradiol, thereby suppressing the trophic effects of estradiol on both eutopic and ectopic endometrium. It also has a local progestogenic effect on the endometrium, leading to decidualization and subsequent atrophy of endometrial lesions. For contraception, it suppresses ovulation.

Pharmacokinetics

Onset

Within 24 hours (for endometrial effects, symptomatic relief may take weeks)

Excretion

Mainly excreted via the kidneys (primarily as metabolites) and to a lesser extent via feces.

Half life

Approximately 9-10 hours

Absorption

Rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are reached about 1.5 hours after intake.

Metabolism

Extensively metabolized by the cytochrome P450 3A4 system (CYP3A4) into pharmacologically inactive metabolites.

Side Effects

Contraindications

Active venous thromboembolic disorder
History of arterial or cardiovascular disease
Diabetes mellitus with vascular involvement
Severe hepatic disease
Undiagnosed vaginal bleeding
Known or suspected hormone-dependent malignant tumours
Hypersensitivity to the active substance or any excipients

Drug Interactions

Herbal medicines (e.g., St. John's Wort)

May reduce efficacy due to enzyme induction.

CYP3A4 Inducers (e.g., Rifampicin, Phenytoin, Carbamazepine)

May reduce Dienogest plasma concentrations and therapeutic effects.

CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin, Grapefruit juice)

May increase Dienogest plasma concentrations, leading to increased side effects.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Overdose may cause nausea, vomiting, and slight vaginal bleeding. No specific antidote exists. Treatment should be symptomatic.

Pregnancy & Lactation

Liana is contraindicated during pregnancy. It is not recommended during breastfeeding as Dienogest is excreted in breast milk and may affect the infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1x14 tablets1x28 tablets

Shelf Life

36 months from manufacturing date

Availability

Pharmacies, hospitals

Approval Status

Approved by regulatory authorities

Patent Status

Generic versions available, original patent expired

Clinical Trials

Dienogest has been studied extensively in clinical trials for the treatment of endometriosis, demonstrating significant reduction in pain and lesion size. Further trials confirm its efficacy and safety profile.

Lab Monitoring

Regular blood pressure monitoring
Lipid profile (periodically)
Liver function tests (if symptoms arise)
Bone mineral density (for long-term use)

Doctor Notes

Counsel patients on potential changes in bleeding patterns.
Assess VTE risk factors before initiation and periodically during treatment.
Monitor liver function in patients with a history of hepatic dysfunction.

Patient Guidelines

Take the tablet at the same time every day.
Do not stop taking the tablet without consulting your doctor.
Inform your doctor about all other medications you are taking.
Report any unusual bleeding or severe pain immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses at once. If more than 12 hours have passed, discard the missed tablet and continue with the next tablet at the regular time. Use additional non-hormonal contraception if necessary.

Driving Precautions

Liana is not expected to affect the ability to drive or operate machinery. However, if you experience side effects like dizziness, avoid driving until you feel well.

Lifestyle Advice

Maintain a healthy diet and regular exercise.
Avoid smoking, especially if you are over 35 years old, due to increased risk of cardiovascular events.
Limit alcohol intake.