Medicine Information

Liftear

Name: Liftear
Brand: Liftear
Rating: 4.5 (117 reviews)

Eye Drop (Ophthalmic Solution)5%Immunomodulators, Ophthalmic agents, Drugs for dry eyeATC: S01XA

Generic Name

Lifitegrast Ophthalmic Solution

Manufacturer

Incepta Pharmaceuticals

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
liftear 5 eye drop	৳ 1,500.00	N/A

Description

Overview of the medicine

Lifitegrast ophthalmic solution is used to treat the signs and symptoms of dry eye disease. It works by blocking the interaction between LFA-1 and ICAM-1, reducing inflammation associated with the condition.

Uses & Indications

Treatment of signs and symptoms of dry eye disease (DED).

Dosage

Adults

One drop in each eye twice daily (approximately 12 hours apart).

Elderly

No dosage adjustment required.

Renal_impairment

Not studied, but minimal systemic absorption suggests no adjustment needed.

How to Take

For topical ocular use only. Instill one drop into each eye. Invert the closed single-use container several times to mix the emulsion before use. Use immediately after opening and discard any remaining solution. Do not touch the tip of the dropper to the eye or any other surface.

Mechanism of Action

Lifitegrast is a lymphocyte function-associated antigen-1 (LFA-1) antagonist. It binds to LFA-1, a cell surface protein on T-lymphocytes, and blocks the interaction of LFA-1 with its cognate ligand, intercellular adhesion molecule-1 (ICAM-1). This inhibition prevents T-cell activation and migration, thereby reducing inflammation associated with dry eye disease.

Pharmacokinetics

Onset

Symptomatic improvement typically observed after 2-4 weeks of treatment.

Excretion

Primarily through the kidneys via urine.

Half life

Systemic half-life approximately 24 hours.

Absorption

Minimal systemic absorption following topical ocular administration.

Metabolism

Not extensively metabolized; primarily excreted unchanged or as minor metabolites.

Side Effects

Contraindications

Hypersensitivity to lifitegrast or any components of the formulation.

Drug Interactions

General

No formal drug interaction studies have been conducted. Systemic exposure is low, so systemic interactions are unlikely.

Storage

Store at 20°C to 25°C (68°F to 77°F). Protect from light. Do not freeze.

Overdose

Overdose is unlikely with topical ocular administration. If accidentally ingested, seek medical advice.

Pregnancy & Lactation

Pregnancy: No adequate and well-controlled studies in pregnant women. Use only if potential benefit justifies potential risk to the fetus. Lactation: It is not known whether lifitegrast is excreted in human milk. Exercise caution when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 single-use containers (0.2 mL each)

Shelf Life

Typically 24-36 months, refer to product labeling for exact duration.

Availability

Pharmacies, Hospitals

Approval Status

FDA Approved (for Xiidra, original brand), DGDA Approved (for local brand)

Patent Status

Patented (for original innovator)

Clinical Trials

Demonstrated efficacy in multiple randomized, controlled clinical trials for dry eye disease, showing improvement in both signs and symptoms.

Lab Monitoring

No specific lab monitoring required.

Doctor Notes

Educate patients on proper instillation technique to minimize the risk of contamination and maximize efficacy.
Advise patients that full therapeutic effects may take several weeks to manifest.
Consider a trial period of at least 6-12 weeks to assess patient response.

Patient Guidelines

Do not wear contact lenses during treatment.
Wash hands before and after use.
Avoid touching the tip of the container to the eye or any other surface to prevent contamination.
Use one single-use container for each dose and discard after use.

Missed Dose Advice

If a dose is missed, continue with the next dose at the regular scheduled time. Do not take a double dose to make up for a missed one.

Driving Precautions

May cause temporary blurred vision or irritation immediately after instillation. Patients should be advised to wait until vision clears before driving or operating machinery.