Medicine Information

Lucidol

Name: Lucidol
Brand: Lucidol
Rating: 4.5 (117 reviews)

Suppository100 mgNon-steroidal Anti-inflammatory Drugs (NSAIDs)ATC: M01AB01

Generic Name

Indomethacin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
lucidol 100 mg suppository	৳ 15.00	N/A

Description

Overview of the medicine

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and fever. Lucidol 100 mg Suppository is a rectal formulation primarily used for conditions such as arthritis, gout, and other inflammatory disorders.

Uses & Indications

Rheumatoid arthritis

Osteoarthritis

Ankylosing spondylitis

Acute painful shoulder

Acute gouty arthritis

Postoperative pain

Fever (resistant to other antipyretics, in specific cases)

Dosage

Adults

Typically 50-100 mg rectally, 1-2 times daily. Max 200 mg/day. Dosage should be individualized and lowest effective dose used.

Elderly

Lower doses may be required due to increased risk of side effects and impaired renal function. Start with 50 mg once daily.

Renal_impairment

Reduced dosage and careful monitoring are necessary due to risk of renal toxicity. Avoid in severe renal impairment.

How to Take

For rectal use only. Remove the suppository from its wrapper and insert it into the rectum. Lie down for a few minutes after insertion.

Mechanism of Action

Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing prostaglandin synthesis, which are mediators of pain, inflammation, and fever.

Pharmacokinetics

Onset

Within 30 minutes to 1 hour, full effect within a few hours.

Excretion

Excreted primarily in urine (60%) and feces (33%) as metabolites and some unchanged drug.

Half life

Approximately 4.5 hours, but can vary.

Absorption

Well absorbed from the rectum, though onset may be slower than oral forms. Peak plasma concentrations are reached within 2-4 hours.

Metabolism

Primarily in the liver by O-demethylation and N-deacylation, followed by glucuronidation.

Side Effects

Contraindications

Hypersensitivity to indomethacin or other NSAIDs
Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Active peptic ulcer or gastrointestinal bleeding
Severe renal or hepatic impairment
Severe heart failure
Third trimester of pregnancy
Proctitis or recent rectal bleeding

Drug Interactions

Lithium

Increased plasma lithium levels, leading to toxicity.

Methotrexate

Increased plasma methotrexate levels, leading to toxicity.

Corticosteroids

Increased risk of gastrointestinal ulceration and bleeding.

Diuretics (e.g., Furosemide)

Reduced diuretic and antihypertensive effects.

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Antiplatelet agents (e.g., Aspirin)

Increased risk of gastrointestinal bleeding and reduced antiplatelet effect of aspirin.

ACE inhibitors/Angiotensin II receptor blockers

Reduced antihypertensive effect and increased risk of renal impairment.

Storage

Store below 30°C in a dry place, away from light. Do not freeze.

Overdose

Symptoms may include nausea, vomiting, epigastric pain, headache, drowsiness, and central nervous system depression. Management is supportive and symptomatic, including gastric lavage or induced emesis if oral overdose, but for suppository, symptomatic treatment is key. Monitor vital signs and renal function.

Pregnancy & Lactation

Category C in first two trimesters, Category D in third trimester. Avoid in late pregnancy due to risk of premature closure of ductus arteriosus. Use with caution during lactation; small amounts are excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 suppositories/box10 suppositories/box

Shelf Life

Typically 24 to 36 months from manufacturing date.

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical data supports the efficacy and safety of indomethacin for its approved indications. Ongoing research explores new formulations or indications.

Lab Monitoring

Complete Blood Count (CBC) (for anemia, bleeding)
Renal function tests (BUN, creatinine)
Liver function tests (ALT, AST)
Blood pressure monitoring

Doctor Notes

Advise patients on proper rectal administration technique.
Monitor patients for signs of GI bleeding or renal dysfunction, especially with long-term use.
Exercise caution in patients with a history of cardiovascular disease or risk factors.

Patient Guidelines

Use the suppository rectally as directed by your doctor.
Do not take by mouth.
Wash your hands before and after handling the suppository.
Do not exceed the recommended dose.
Report any unusual bleeding, severe abdominal pain, or black/tarry stools to your doctor immediately.