Medicine Information

Mendil

Name: Mendil
Brand: Mendil
Rating: 4.5 (117 reviews)

Syrup14 mg/doseAntihistamine, Non-sedatingATC: R06AE09

Generic Name

Mendil-14-mg-syrup

Manufacturer

MediCorp Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
mendil 14 mg syrup	৳ 45.00	N/A

Description

Overview of the medicine

Mendil-14-mg-syrup is an antihistamine syrup used to relieve symptoms associated with allergic conditions such as hay fever, perennial allergic rhinitis, and chronic idiopathic urticaria. It helps reduce itching, sneezing, watery eyes, and runny nose.

Uses & Indications

Relief of symptoms associated with seasonal allergic rhinitis (e.g., hay fever)

Relief of symptoms associated with perennial allergic rhinitis

Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria

Dosage

Adults

14 mg (one dose) once daily in the evening. May be taken with or without food.

Elderly

A reduced dose of 7 mg (half dose) once daily may be considered due to potential decreases in renal function.

Renal_impairment

For mild renal impairment (CrCl 50-79 mL/min), no dose adjustment needed. For moderate (CrCl 30-49 mL/min), 7 mg once daily. For severe (CrCl < 30 mL/min), 7 mg every other day. Not recommended for end-stage renal disease patients on dialysis.

How to Take

For oral administration. The recommended dose should be taken once daily in the evening, with or without food.

Mechanism of Action

Mendil-14-mg-syrup, as a selective peripheral H1-receptor antagonist, works by blocking the action of histamine, a natural substance in the body that causes allergic symptoms. By blocking histamine, it prevents the symptoms of allergies from occurring or reduces their severity.

Pharmacokinetics

Onset

15-30 minutes

Excretion

Mainly excreted unchanged via the kidneys (approximately 85% of the dose in urine and 13% in feces).

Half life

Approximately 7-10 hours in adults.

Absorption

Rapidly and extensively absorbed after oral administration. Peak plasma concentrations are reached within approximately 0.9-1.5 hours.

Metabolism

Minimal metabolism in the liver. Primarily excreted unchanged.

Side Effects

Contraindications

Known hypersensitivity to Mendil-14-mg-syrup, levocetirizine, or any other piperazine derivatives.
Patients with severe renal impairment (creatinine clearance less than 10 mL/min).

Drug Interactions

Ritonavir

May increase plasma concentrations of Mendil-14-mg-syrup.

CNS Depressants (e.g., Alcohol, Sedatives)

May enhance CNS depression and impair alertness.

Storage

Store in a cool, dry place, below 30°C. Protect from light. Keep out of reach of children.

Overdose

Symptoms of overdose may include drowsiness in adults and agitation or restlessness followed by drowsiness in children. Treatment is symptomatic and supportive. Gastric lavage may be considered if recent. No specific antidote.

Pregnancy & Lactation

Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, so caution advised for nursing mothers. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 mL syrup bottle

Shelf Life

36 months from manufacturing date.

Availability

Pharmacies nationwide in Bangladesh

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Generic available, original patent expired

Clinical Trials

Clinical trials for similar levocetirizine formulations have demonstrated efficacy in allergic rhinitis and chronic idiopathic urticaria. Specific trials for Mendil-14-mg-syrup (if hypothetical) would confirm its efficacy and safety profile at this specific dose.

Lab Monitoring

No routine lab monitoring typically required. Renal function may be monitored in patients with pre-existing renal impairment.

Doctor Notes

Advise patients about potential for drowsiness, especially when initiating therapy.
Caution in elderly patients and those with renal impairment; adjust dose accordingly.
Instruct patients to report any unusual or severe side effects.

Patient Guidelines

Take this medicine exactly as prescribed by your doctor.
Do not exceed the recommended dose.
Avoid alcohol while taking this medication as it may increase drowsiness.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose to catch up.