Medicine Information

Metrozen

Name: Metrozen
Brand: Metrozen
Rating: 4.5 (117 reviews)

Suspension200 mg/5 mlAmoebicides, Anti-protozoal, Anti-bacterialATC: P01AB01

Generic Name

Metronidazole

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
metrozen 200 mg suspension	৳ 35.00	N/A

Description

Overview of the medicine

Metrozen 200 mg Suspension contains Metronidazole, an antibiotic and antiprotozoal medication used to treat a wide range of infections caused by anaerobic bacteria and certain parasites.

Uses & Indications

Amoebiasis (intestinal and hepatic)

Giardiasis

Trichomoniasis

Bacterial vaginosis

Anaerobic bacterial infections (e.g., intra-abdominal, skin, gynecological, respiratory tract infections)

Dosage

Adults

Typically 400-800 mg orally 2-3 times daily for 5-10 days depending on the infection. For severe infections, higher doses may be used.

Elderly

No specific dose adjustment for elderly patients with normal renal and hepatic function, but caution is advised.

Renal_impairment

Dose reduction may be necessary in severe renal impairment, especially with repeated dosing, due to accumulation of metabolites.

How to Take

Shake well before use. Administer orally with or after food to minimize gastrointestinal upset. Use a measuring spoon or cup for accurate dosing.

Mechanism of Action

Metronidazole is a nitroimidazole derivative. It enters the cell of susceptible organisms and is reduced by electron transport proteins to form reactive nitro-radicals. These radicals disrupt DNA synthesis and cause DNA damage, leading to cell death.

Pharmacokinetics

Onset

Typically within a few hours for symptomatic relief.

Excretion

Mainly renal (60-80%), with a smaller amount excreted in feces (6-15%).

Half life

Approximately 8 hours (range 6-12 hours).

Absorption

Well absorbed orally, with peak plasma concentrations occurring 1-2 hours after administration.

Metabolism

Primarily hepatic, mainly by oxidation with side-chain cleavage and glucuronide conjugation.

Side Effects

Contraindications

Hypersensitivity to metronidazole or other nitroimidazole derivatives
First trimester of pregnancy (relative contraindication, generally avoided unless essential)

Drug Interactions

Alcohol

Disulfiram-like reaction (nausea, vomiting, flushing, tachycardia, dyspnea) due to inhibition of alcohol dehydrogenase. Avoid alcohol during and for at least 48 hours after treatment.

Warfarin

Potentiates anticoagulant effect, increased risk of bleeding. INR monitoring required.

Storage

Store below 30°C in a dry place, protected from light. Do not freeze.

Overdose

Symptoms of overdose include nausea, vomiting, ataxia, and mild disorientation. Treatment is symptomatic and supportive; there is no specific antidote.

Pregnancy & Lactation

Pregnancy Category B. Generally avoided in the first trimester. Use in second and third trimesters only if clearly needed. Excreted into breast milk, therefore, either discontinue breastfeeding or interrupt metronidazole treatment for 12-24 hours.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 ml suspension100 ml suspension

Shelf Life

Typically 2-3 years, check package for specific expiry date.

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies globally

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied and widely used for decades. Ongoing research focuses on resistance patterns and new applications.

Lab Monitoring

Liver function tests (especially in hepatic impairment)
Complete blood count (for prolonged therapy)

Doctor Notes

Counsel patients to avoid alcohol completely.
Monitor for signs of neurological adverse effects during prolonged treatment.
Consider liver and renal function in impaired patients.

Patient Guidelines

Complete the full course of treatment even if symptoms improve.
Avoid alcohol during treatment and for at least 2 days after.
Take with or after food to reduce stomach upset.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.