Nitrobac

Take with food or milk to enhance absorption and minimize gastrointestinal upset. Swallow whole with water.

Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates that inactivate or damage bacterial ribosomal proteins, DNA, RNA, and other macromolecules.

• Renal impairment (creatinine clearance <60 mL/min).
• History of cholestatic jaundice or hepatic dysfunction associated with prior nitrofurantoin use.
• Infants younger than one month.
• Third trimester of pregnancy (due to risk of hemolytic anemia in the newborn).

Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.

Symptoms may include nausea, vomiting, and diarrhea. Management is supportive; induce emesis or gastric lavage if recent ingestion. Maintain adequate hydration. Hemodialysis is ineffective.

Pregnancy: Category B. Avoid in the third trimester due to risk of hemolytic anemia in the newborn. Use with caution in other trimesters if benefits outweigh risks. Lactation: Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential side effects (e.g., hemolytic anemia in G6PD-deficient infants).