Osetron
Generic Name
Ondansetron
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| osetron 8 mg injection | ৳ 32.00 | N/A |
Description
Overview of the medicine
Osetron 8 mg Injection contains Ondansetron, a medication used to prevent nausea and vomiting, especially those associated with cancer chemotherapy, radiation therapy, and surgery.
Uses & Indications
Dosage
Adults
Chemotherapy-induced nausea and vomiting (CINV): Highly emetogenic, 24 mg IV single dose or 8 mg IV/IM before chemotherapy. Moderately emetogenic, 8 mg IV/IM before chemotherapy, repeated 8 hours later. Post-operative nausea and vomiting (PONV): 4 mg IV single dose immediately before anesthesia induction or post-operatively.
Elderly
Generally no dose adjustment needed. Caution in patients with severe hepatic impairment.
Renal_impairment
No dose adjustment required for renal impairment.
How to Take
Administer by slow intravenous injection (over at least 30 seconds, preferably over 2-5 minutes) or intramuscular injection. May be diluted in dextrose 5% or sodium chloride 0.9% solution.
Mechanism of Action
Ondansetron is a selective serotonin 5-HT3 receptor antagonist. It works by blocking the action of serotonin, a natural substance that can cause nausea and vomiting, particularly in the chemoreceptor trigger zone and on vagal afferents in the gastrointestinal tract.
Pharmacokinetics
Onset
Within 30 minutes (intravenous).
Excretion
Primarily excreted via urine (5-10% as unchanged drug) and feces (metabolites).
Half life
Approximately 3-5 hours.
Absorption
Rapidly and completely absorbed following intravenous administration, with 100% bioavailability.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP1A2, CYP2D6, CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to ondansetron or any component of the formulation.
- Concomitant use with apomorphine due to profound hypotension and loss of consciousness.
Drug Interactions
Tramadol
May reduce the analgesic effect of tramadol.
Apomorphine
Concomitant use is contraindicated due to severe hypotension and loss of consciousness.
QT-prolonging drugs
Increased risk of QT prolongation and Torsade de Pointes. Use with caution.
Storage
Store below 30°C (86°F). Protect from light. Do not freeze.
Overdose
Overdose symptoms include visual disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. Management should be symptomatic and supportive, including ECG monitoring.
Pregnancy & Lactation
Pregnancy Category B. Should be used during pregnancy only if clearly needed. Ondansetron is excreted in human breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored as recommended.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Ondansetron has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for preventing chemotherapy-induced nausea and vomiting (CINV), radiation-induced nausea and vomiting (RINV), and post-operative nausea and vomiting (PONV).
Lab Monitoring
- ECG monitoring in patients with underlying cardiac conditions or receiving other QT-prolonging drugs.
- Liver function tests in patients with severe hepatic impairment or prolonged use.
Doctor Notes
- Monitor ECG in patients with risk factors for QT prolongation.
- Be aware of potential drug interactions, especially with apomorphine and tramadol.
- Ensure correct administration technique for IV/IM injection.
Patient Guidelines
- Inform your doctor about all your medical conditions and medications.
- Report any severe headache, dizziness, or irregular heartbeat immediately.
- Do not stop the medication without consulting your doctor.
Missed Dose Advice
If part of a multi-day regimen for chemotherapy, administer the missed dose as soon as remembered. Do not double the dose.
Driving Precautions
Ondansetron may cause dizziness or drowsiness. Patients should be cautioned about operating hazardous machinery or driving until they are reasonably certain that ondansetron does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Avoid alcohol consumption, which can exacerbate nausea.
- Maintain hydration, especially during chemotherapy.
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