Medicine Information

afexa

Name: afexa
Brand: afexa
Rating: 4.5 (117 reviews)

Tablet120 mgAntihistamine, Non-sedating; AntiallergicATC: R06AX26

Generic Name

Fexofenadine Hydrochloride 120 mg Tablet

Manufacturer

Acme Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
afexa 120 mg tablet	৳ 9.00	৳ 90.00

Description

Overview of the medicine

Afexa 120 mg Tablet contains Fexofenadine Hydrochloride, a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria. It works by blocking histamine H1 receptors, thereby reducing allergic reactions like sneezing, runny nose, itchy eyes, and skin rashes.

Uses & Indications

Relief of symptoms associated with seasonal allergic rhinitis in adults and children 12 years of age and older (e.g., sneezing, rhinorrhea, itchy nose/palate/throat, itchy/watery/red eyes).

Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 12 years of age and older (e.g., relief of pruritus and decrease in the number of wheals).

Dosage

Adults

Seasonal Allergic Rhinitis: 120 mg once daily. Chronic Idiopathic Urticaria: 180 mg once daily (if available, otherwise 120 mg once daily for rhinitis symptoms).

Elderly

No specific dosage adjustment is generally required, but caution is advised in patients with impaired renal or hepatic function.

Renal_impairment

For patients with moderate to severe renal impairment (creatinine clearance < 80 mL/min), initial dose of 60 mg once daily is recommended. Use with caution.

How to Take

Take the tablet orally with water, preferably before a meal. Do not take with fruit juice.

Mechanism of Action

Fexofenadine is a selective peripheral H1-receptor antagonist. It binds to histamine H1 receptors in the body, blocking the action of histamine, which is a key mediator of allergic reactions. This leads to a reduction in allergy symptoms without significant sedation, as it does not readily cross the blood-brain barrier.

Pharmacokinetics

Onset

Within 1 hour

Excretion

Primarily excreted in feces (approximately 80%) and urine (approximately 11%) as unchanged drug.

Half life

Approximately 11-15 hours

Absorption

Rapidly absorbed after oral administration. Peak plasma concentrations are reached in 1-3 hours.

Metabolism

Minimally metabolized; approximately 5% of the total dose is metabolized (mainly hepatic).

Side Effects

Contraindications

Hypersensitivity to Fexofenadine Hydrochloride or any component of the formulation.

Drug Interactions

Erythromycin or Ketoconazole

Can increase plasma levels of fexofenadine, potentially leading to increased side effects, though generally not clinically significant.

Antacids (aluminum and magnesium containing)

May reduce the bioavailability of fexofenadine. Separate administration by at least 2 hours.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, common symptoms may include dizziness, drowsiness, and dry mouth. Treatment should be symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted in human breast milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10)30 tablets (3x10)

Shelf Life

24 months from manufacturing date

Availability

Pharmacies nationwide

Approval Status

Approved by regulatory bodies

Patent Status

Generic available

Clinical Trials

Extensive clinical trials have demonstrated Fexofenadine's efficacy and safety in treating allergic rhinitis and chronic idiopathic urticaria. Studies confirm its non-sedating profile.

Lab Monitoring

No routine lab monitoring is generally required for fexofenadine therapy.

Doctor Notes

Advise patients to avoid taking with fruit juices.
Reassure patients about its non-sedating properties compared to first-generation antihistamines.
Monitor for any signs of hypersensitivity reactions.

Patient Guidelines

Take exactly as prescribed by your doctor.
Do not exceed the recommended dose.
Avoid taking with fruit juices.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

This medicine is generally non-sedating, but some individuals may experience drowsiness or dizziness. If you experience these effects, avoid driving or operating machinery.