Medicine Information

Clincin

Name: Clincin
Brand: Clincin
Rating: 4.5 (117 reviews)

Capsule300 mgAntibiotics (Lincosamide)ATC: J01FF01

Generic Name

Clindamycin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
clincin 300 mg capsule	৳ 15.03	৳ 150.33

Description

Overview of the medicine

Clindamycin is a lincosamide antibiotic used to treat various bacterial infections, including skin and soft tissue infections, respiratory tract infections, and intra-abdominal infections.

Uses & Indications

Serious infections of the respiratory tract (e.g., pneumonia, empyema)

Serious skin and soft tissue infections (e.g., cellulitis, abscesses)

Intra-abdominal infections (e.g., peritonitis, intra-abdominal abscesses)

Gynaecological infections (e.g., pelvic inflammatory disease, endometritis)

Bone and joint infections (e.g., osteomyelitis, septic arthritis)

Septicaemia, Dental infections

Dosage

Adults

150-450 mg every 6-8 hours, depending on the severity of the infection. For Clincin 300 mg capsule, typically 300 mg every 6-8 hours.

Elderly

No specific dosage adjustment is generally required based on age alone, but monitor renal and hepatic function.

Renal_impairment

In severe renal impairment (CrCl < 30 mL/min), dosage adjustment may be necessary. Consider extending the dosing interval or reducing the dose. No adjustment needed for mild to moderate impairment.

How to Take

Take orally with a full glass of water, with or without food. To minimize the risk of esophageal irritation, do not lie down for at least 30 minutes after taking the capsule.

Mechanism of Action

Clindamycin binds to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting bacterial protein synthesis. It typically acts as a bacteriostatic agent.

Pharmacokinetics

Onset

Antibacterial effect typically begins within 30-60 minutes after oral administration.

Excretion

Approximately 10-20% of the dose is excreted in the urine, and about 4% is excreted in the feces, primarily as active drug and metabolites. The remainder is eliminated via biliary excretion.

Half life

The elimination half-life is approximately 2 to 3 hours in adults, which may be slightly prolonged in patients with severe renal or hepatic impairment.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached in approximately 45-60 minutes.

Metabolism

Extensively metabolized in the liver to active (e.g., N-demethyl clindamycin) and inactive metabolites. CYP3A4 and to a lesser extent CYP3A5 are the principal enzymes involved.

Side Effects

Contraindications

Hypersensitivity to clindamycin, lincomycin, or any component of the formulation.
History of antibiotic-associated colitis, especially *Clostridioides difficile*-associated diarrhea.

Drug Interactions

Erythromycin

Antagonism between clindamycin and erythromycin has been demonstrated *in vitro*. Avoid co-administration.

Kaolin-pectin

May reduce the absorption of clindamycin. Administer at least 2 hours apart.

Neuromuscular Blocking Agents

Clindamycin has neuromuscular blocking properties and may enhance the action of other neuromuscular blocking agents. Use with caution.

Oral Anticoagulants (e.g., Warfarin)

May increase the effects of vitamin K antagonists. Monitor INR (International Normalized Ratio) closely.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

In case of overdose, symptomatic and supportive treatment is recommended. There is no specific antidote for clindamycin, and it is not effectively removed by hemodialysis or peritoneal dialysis.

Pregnancy & Lactation

Pregnancy Category B. Use in pregnancy only if clearly needed. Clindamycin is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules (1x10 strip)30 capsules (3x10 strips)

Shelf Life

24 months from the date of manufacture.

Availability

Pharmacies, Hospitals, Clinics

Approval Status

Approved (DGDA, FDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Clindamycin is a well-established antibiotic. While initial clinical trials supported its efficacy and safety decades ago, ongoing research focuses on resistance patterns, new formulations, and specific populations.

Lab Monitoring

Periodic liver and kidney function tests for prolonged therapy.
Complete blood count (CBC) during prolonged therapy.
Stool examination for *Clostridioides difficile* if severe diarrhea occurs.

Doctor Notes

Emphasize the risk of *Clostridioides difficile*-associated diarrhea to patients, advising them to report severe or persistent diarrhea.
Consider liver and kidney function monitoring, along with CBC, for patients on prolonged clindamycin therapy.
Avoid co-administration with erythromycin due to *in vitro* antagonism.

Patient Guidelines

Complete the entire prescribed course of medicine, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
Report any persistent or severe diarrhea, especially if bloody or watery, to your doctor immediately.
Take capsules with a full glass of water and remain upright for at least 30 minutes to prevent esophageal irritation.
Do not share this medicine with others, even if they have similar symptoms.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Clindamycin is generally not expected to impair the ability to drive or operate machinery. However, if you experience side effects like dizziness, avoid such activities.