Medicine Information

Corzil

Name: Corzil
Brand: Corzil
Rating: 4.5 (117 reviews)

Tablet40 mgAngiotensin II Receptor Blocker (ARB)ATC: C09CA07

Generic Name

Telmisartan 40 mg Tablet

Manufacturer

Beximco Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
corzil 40 mg tablet	৳ 12.00	৳ 120.00

Description

Overview of the medicine

Corzil 40 mg Tablet contains Telmisartan, an Angiotensin Receptor Blocker (ARB) used for the treatment of essential hypertension and to reduce cardiovascular morbidity and mortality in patients aged 55 years or older at high risk of cardiovascular events.

Uses & Indications

Treatment of essential hypertension.

Reduction of cardiovascular morbidity and mortality in patients aged 55 years or older at high risk of cardiovascular events.

Dosage

Adults

The usual recommended dose is 40 mg once daily. The dose may be increased to a maximum of 80 mg once daily if necessary.

Elderly

No dose adjustment is necessary for elderly patients.

Renal_impairment

No dose adjustment is required for patients with mild to moderate renal impairment. For severe impairment, close monitoring is recommended.

How to Take

Corzil tablets are for oral use and should be taken once daily with or without food. Swallow the tablet whole with water.

Mechanism of Action

Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor in many tissues, including vascular smooth muscle and the adrenal gland. This leads to inhibition of the vasoconstrictor and aldosterone-secreting effects of angiotensin II, resulting in vasodilation and reduced blood pressure.

Pharmacokinetics

Onset

Antihypertensive effect usually starts within 3 hours after a single oral dose.

Excretion

Primarily excreted unchanged in feces (about 97%).

Half life

Approximately 24 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract. Absolute bioavailability varies with dose: approximately 42% for 40 mg and 58% for 160 mg.

Metabolism

Metabolized by conjugation to form an acylglucuronide, which is pharmacologically inactive.

Side Effects

Contraindications

Hypersensitivity to the active substance or to any of the excipients.
Second and third trimesters of pregnancy.
Biliary obstructive disorders.
Severe hepatic impairment.
Concomitant use of Aliskiren in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m²).

Drug Interactions

Digoxin

Increased plasma concentrations of digoxin have been reported when co-administered with telmisartan.

Lithium

Concurrent use may lead to reversible increases in serum lithium concentrations and toxicity.

Aliskiren

Contraindicated in patients with diabetes or renal impairment due to increased risk of hypotension, hyperkalemia, and worsening renal function.

Diuretics (Thiazide or loop diuretics)

May increase the risk of symptomatic hypotension.

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

May reduce the antihypertensive effect of Telmisartan and increase the risk of renal impairment.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Limited data are available concerning overdose in humans. The most likely manifestations would be hypotension, tachycardia, or bradycardia. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.

Pregnancy & Lactation

Telmisartan is contraindicated during the second and third trimesters of pregnancy due to the risk of fetal harm. It is not recommended during the first trimester and during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister pack30 tablets per box

Shelf Life

36 months from the date of manufacture.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by DGDA/FDA

Patent Status

Off-patent

Clinical Trials

Key clinical trials for Telmisartan include the ONTARGET (Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) which investigated its efficacy in reducing cardiovascular events, and the TREND (Telmisartan Randomized ENdpoint Study in Diabetic Nephropathy) which studied its effects in diabetic nephropathy.

Lab Monitoring

Serum potassium levels (especially in patients with renal impairment or those taking potassium-sparing diuretics).
Renal function (creatinine, GFR) periodically.

Doctor Notes

Advise patients on the importance of consistent medication adherence for optimal blood pressure control.
Monitor renal function and serum potassium levels regularly, especially in high-risk groups.
Educate patients about potential symptoms of hypotension and hyperkalemia.

Patient Guidelines

Take Corzil exactly as prescribed by your doctor, even if you feel well.
Do not stop taking Corzil abruptly without consulting your doctor, as this may worsen your condition.
Regularly monitor your blood pressure at home if advised by your doctor.
Report any unusual side effects or worsening symptoms to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Corzil may cause dizziness or drowsiness in some individuals. Patients should be cautioned against driving or operating machinery until they know how Corzil affects them.

Lifestyle Advice

Adopt a healthy lifestyle including a balanced diet, regular exercise, and stress management.
Reduce salt intake and avoid foods high in saturated and trans fats.
Limit alcohol consumption and avoid smoking.