Medicine Information

Eto

Tablet120 mgNSAIDs (Non-steroidal Anti-inflammatory Drugs)ATC: M01AH05

Generic Name

Etoricoxib 120 mg Tablet

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
eto 120 mg tablet	৳ 12.00	৳ 120.00

Description

Overview of the medicine

Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) specifically a COX-2 selective inhibitor. It is used for the treatment of various inflammatory and painful conditions.

Uses & Indications

Acute and chronic osteoarthritis

Rheumatoid arthritis

Ankylosing spondylitis

Acute gouty arthritis

Primary dysmenorrhea

Acute pain, including postoperative dental pain

Dosage

Adults

For Osteoarthritis: 60 mg once daily. For Rheumatoid Arthritis, Ankylosing Spondylitis: 90 mg once daily. For Acute Gouty Arthritis: 120 mg once daily for a maximum of 8 days. For Acute Pain, Primary Dysmenorrhea: 120 mg once daily for a maximum of 8 days.

Elderly

No dose adjustment required, but caution is advised. Initiate at the lowest effective dose.

Renal_impairment

Mild to moderate impairment: No dose adjustment. Severe impairment (CrCl <30 mL/min): Not recommended.

How to Take

Orally, with or without food. For faster onset, it can be taken without food.

Mechanism of Action

Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins, mediators of pain, inflammation, and fever.

Pharmacokinetics

Onset

Pain relief typically begins within 24 minutes for acute conditions.

Excretion

Excreted primarily via urine (70%) and feces (20%) as metabolites.

Half life

Approximately 22 hours.

Absorption

Rapidly absorbed after oral administration, peak plasma concentration reached in approximately 1 hour.

Metabolism

Extensively metabolized in the liver, primarily by cytochrome P450 (CYP3A4) to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to etoricoxib or any component of the formulation
Active peptic ulceration or gastrointestinal bleeding
Severe hepatic impairment
Severe renal impairment (CrCl <30 mL/min)
Congestive heart failure (NYHA II-IV)
Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
Pregnancy and lactation

Drug Interactions

Lithium

Increased plasma lithium levels, leading to toxicity.

Warfarin

Increased risk of bleeding.

Methotrexate

Increased plasma methotrexate levels, leading to toxicity.

ACE inhibitors/ARBs

Reduced antihypertensive effect and increased risk of renal impairment.

Oral Contraceptives

Increased plasma concentration of oral contraceptives.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms include gastrointestinal disturbances (e.g., nausea, vomiting, abdominal pain), somnolence. Management is supportive; there is no specific antidote. Gastric decontamination (e.g., activated charcoal) may be considered within an hour of ingestion.

Pregnancy & Lactation

Contraindicated during pregnancy and lactation. NSAIDs, including etoricoxib, may cause premature closure of the fetal ductus arteriosus if used in the third trimester of pregnancy.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per pack30 tablets per pack

Shelf Life

Typically 2-3 years from manufacturing date.

Availability

Pharmacies and hospitals worldwide

Approval Status

Approved by regulatory authorities worldwide including DGDA (Bangladesh)

Patent Status

Generic versions available, original patent expired in most regions

Clinical Trials

Extensive clinical trials have demonstrated efficacy and safety in various pain and inflammatory conditions, including osteoarthritis, rheumatoid arthritis, and acute pain.

Lab Monitoring

Liver function tests (ALT, AST)
Kidney function tests (Serum creatinine, eGFR)
Blood pressure monitoring
Complete blood count (CBC) during long-term therapy

Doctor Notes

Prescribe at the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Monitor blood pressure regularly during etoricoxib treatment.
Consider concomitant gastroprotective agents in patients at high risk of GI complications.

Patient Guidelines

Take as directed by your doctor.
Do not exceed the recommended dose.
Report any signs of gastrointestinal bleeding or severe skin reactions immediately.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.

Driving Precautions

May cause dizziness or somnolence; exercise caution when driving or operating machinery until you know how the medicine affects you.

Lifestyle Advice

Avoid alcohol consumption as it may increase the risk of stomach bleeding.
Maintain a healthy diet and regular exercise to support overall joint health.
Discuss other pain management strategies with your doctor if long-term NSAID use is a concern.